Morphologic and immunophenotypic features of mature T-cell leukemias
. | T-PLL; n = 38 . | Primary SS; n = 32 . | T-LGL leukemia; n = 15 . |
|---|---|---|---|
| Tumor cell morphology, no. (%) | |||
| Mostly prolymphocytoid | 20 (53) | 7 (22) | 1 (7) |
| Mostly small cerebriform | 8 (21) | 14 (44) | 2 (14) |
| Mixed small and large forms | 10 (26) | 11 (34) | 12 (80) |
| Cytoplasmic granules | 3 (8) | 4 (13) | 12 (80) |
| Pattern in bone marrow biopsy, no. (%) | |||
| Nodular | 0 (0) | 1/30 (3) | 1 (7)† |
| Nodular/interstitial | 5 (13) | 6/30 (20) | 10 (67)† |
| Interstitial | 30 (79) | 23/30 (77) | 4 (26) |
| Diffuse | 3 (8) | 0/30 (0) | 0 (0) |
| Sinusoidal | 0 (0) | 0/30 (0) | 0 (0) |
| Tumor immunophenotype by flow cytometry, no. (%) | |||
| CD4+ CD8− | 24 (63) | 30 (94) | 2 (13) |
| CD4+ CD8+ | 12 (32) | 1 (3) | 0 (0) |
| CD4− CD8+ | 2 (5) | 0 (0) | 13 (87) |
| CD4− CD8− | 0 (0) | 1 (3) | 0 (0) |
| CD5+ | 38 (100) | 18/18 (100) | −/dim 9/12 (75) |
| CD7+ | 35/37 (95) | 19/31 (61) | 10/13 (77) |
| CD26+ | 20/26 (77) | 1/32 (3) | 2/11 (18) |
| TCR-α/β+ | 12/14 (86)‡ | 4/4 (100) | 12/14 (86) |
| TCR-γ/δ+ | 0/14 (0)‡ | 0/2 (0) | 2/14 (14) |
| TCL1 expression* | 27/38 (71) | 0/17 (0) | 0/5 (0) |
. | T-PLL; n = 38 . | Primary SS; n = 32 . | T-LGL leukemia; n = 15 . |
|---|---|---|---|
| Tumor cell morphology, no. (%) | |||
| Mostly prolymphocytoid | 20 (53) | 7 (22) | 1 (7) |
| Mostly small cerebriform | 8 (21) | 14 (44) | 2 (14) |
| Mixed small and large forms | 10 (26) | 11 (34) | 12 (80) |
| Cytoplasmic granules | 3 (8) | 4 (13) | 12 (80) |
| Pattern in bone marrow biopsy, no. (%) | |||
| Nodular | 0 (0) | 1/30 (3) | 1 (7)† |
| Nodular/interstitial | 5 (13) | 6/30 (20) | 10 (67)† |
| Interstitial | 30 (79) | 23/30 (77) | 4 (26) |
| Diffuse | 3 (8) | 0/30 (0) | 0 (0) |
| Sinusoidal | 0 (0) | 0/30 (0) | 0 (0) |
| Tumor immunophenotype by flow cytometry, no. (%) | |||
| CD4+ CD8− | 24 (63) | 30 (94) | 2 (13) |
| CD4+ CD8+ | 12 (32) | 1 (3) | 0 (0) |
| CD4− CD8+ | 2 (5) | 0 (0) | 13 (87) |
| CD4− CD8− | 0 (0) | 1 (3) | 0 (0) |
| CD5+ | 38 (100) | 18/18 (100) | −/dim 9/12 (75) |
| CD7+ | 35/37 (95) | 19/31 (61) | 10/13 (77) |
| CD26+ | 20/26 (77) | 1/32 (3) | 2/11 (18) |
| TCR-α/β+ | 12/14 (86)‡ | 4/4 (100) | 12/14 (86) |
| TCR-γ/δ+ | 0/14 (0)‡ | 0/2 (0) | 2/14 (14) |
| TCL1 expression* | 27/38 (71) | 0/17 (0) | 0/5 (0) |