Somatic PTPN11 mutations in childhood acute leukemia
Malignancy, subtype, and nucleotide substitution . | No. of cases . | Amino acid substitution . |
|---|---|---|
| ALL | ||
| Common | ||
| 172A>T | 1 | Asn58Tyr |
| 181G>T | 1 | Asp61Tyr |
| 182A>T | 1 | Asp61Val |
| 205G>A | 2 | Glu69Lys |
| 214G>A | 1 | Ala72Thr |
| 215C>T | 3 | Ala72Val |
| 226G>A | 3 | Glu76Lys |
| 226G>C | 2 | Glu76Gln |
| 227A>G | 1 | Glu76Gly |
| 1471C>T | 1 | Pro491Ser |
| 1472C>T | 1 | Pro491Leu |
| 1504T>C | 1 | Ser502Pro |
| 1528C>A | 1 | Gln510Lys |
| Pre-B | ||
| 215C>A | 1 | Ala72Asp |
| 226G>A | 1 | Glu76Lys |
| 1472C>T | 1 | Pro491Leu |
| Bilineage | ||
| 227A>G | 1* | Glu76Gly |
| AML | ||
| FAB-M5 | ||
| 215C>T | 2† | Ala72Val |
| 226G>A | 1† | Glu76Lys |
| 1520C>A | 1 | Thr507Lys |
Malignancy, subtype, and nucleotide substitution . | No. of cases . | Amino acid substitution . |
|---|---|---|
| ALL | ||
| Common | ||
| 172A>T | 1 | Asn58Tyr |
| 181G>T | 1 | Asp61Tyr |
| 182A>T | 1 | Asp61Val |
| 205G>A | 2 | Glu69Lys |
| 214G>A | 1 | Ala72Thr |
| 215C>T | 3 | Ala72Val |
| 226G>A | 3 | Glu76Lys |
| 226G>C | 2 | Glu76Gln |
| 227A>G | 1 | Glu76Gly |
| 1471C>T | 1 | Pro491Ser |
| 1472C>T | 1 | Pro491Leu |
| 1504T>C | 1 | Ser502Pro |
| 1528C>A | 1 | Gln510Lys |
| Pre-B | ||
| 215C>A | 1 | Ala72Asp |
| 226G>A | 1 | Glu76Lys |
| 1472C>T | 1 | Pro491Leu |
| Bilineage | ||
| 227A>G | 1* | Glu76Gly |
| AML | ||
| FAB-M5 | ||
| 215C>T | 2† | Ala72Val |
| 226G>A | 1† | Glu76Lys |
| 1520C>A | 1 | Thr507Lys |