Prevalence of RAS mutations, TEL-AML1 gene rearrangement, and DNA index in ALL cases with or without mutations in PTPN11
. | Cases analyzed for PTPN11 mutations . | . | . | . | ||
|---|---|---|---|---|---|---|
. | Total no. of cases (%) . | No. of cases without mutations (%) . | No. of cases with mutations (%) . | P . | ||
| RAS mutations | ||||||
| Common ALL | ||||||
| Positive | 40 (26.9) | 39 (29.8) | 1 (5.6) | |||
| Negative | 109 (73.1) | 92 (70.2) | 17 (94.4) | |||
| Total | 149 | 131 | 18 | .043† | ||
| B-cell precursor ALL | ||||||
| Positive | 64 (24.9) | 63 (26.7) | 1 (4.8) | |||
| Negative | 193 (75.1) | 173 (73.3) | 20 (95.2) | |||
| Total | 257 | 236 | 21 | .026‡ | ||
| TEL-AML1 | ||||||
| Common ALL | ||||||
| Positive | 43 (24.9) | 43 (27.7) | 0 | |||
| Negative | 130 (75.1) | 112 (72.3) | 18 (100) | |||
| Total | 173 | 155 | 18 | .007† | ||
| B-cell precursor ALL | ||||||
| Positive | 66 (22.8) | 66 (24.4) | 0 | |||
| Negative | 223 (77.2) | 204 (75.6) | 19 (100) | |||
| Total | 289 | 270 | 19 | .009† | ||
| DNA index | ||||||
| Common ALL | ||||||
| Less than or equal to 1* | 114 (63.3) | 106 (65.8) | 8 (42.1) | |||
| Greater than 1 | 66 (36.7) | 55 (34.2) | 11 (57.9) | |||
| Total | 180 | 161 | 19 | .042‡ | ||
| B-cell precursor ALL | ||||||
| Less than or equal to 1* | 206 (66.9) | 198 (69.2) | 8 (36.4) | |||
| Greater than 1 | 102 (33.1) | 88 (30.8) | 14 (63.6) | |||
| Total | 308 | 286 | 22 | .002‡ | ||
. | Cases analyzed for PTPN11 mutations . | . | . | . | ||
|---|---|---|---|---|---|---|
. | Total no. of cases (%) . | No. of cases without mutations (%) . | No. of cases with mutations (%) . | P . | ||
| RAS mutations | ||||||
| Common ALL | ||||||
| Positive | 40 (26.9) | 39 (29.8) | 1 (5.6) | |||
| Negative | 109 (73.1) | 92 (70.2) | 17 (94.4) | |||
| Total | 149 | 131 | 18 | .043† | ||
| B-cell precursor ALL | ||||||
| Positive | 64 (24.9) | 63 (26.7) | 1 (4.8) | |||
| Negative | 193 (75.1) | 173 (73.3) | 20 (95.2) | |||
| Total | 257 | 236 | 21 | .026‡ | ||
| TEL-AML1 | ||||||
| Common ALL | ||||||
| Positive | 43 (24.9) | 43 (27.7) | 0 | |||
| Negative | 130 (75.1) | 112 (72.3) | 18 (100) | |||
| Total | 173 | 155 | 18 | .007† | ||
| B-cell precursor ALL | ||||||
| Positive | 66 (22.8) | 66 (24.4) | 0 | |||
| Negative | 223 (77.2) | 204 (75.6) | 19 (100) | |||
| Total | 289 | 270 | 19 | .009† | ||
| DNA index | ||||||
| Common ALL | ||||||
| Less than or equal to 1* | 114 (63.3) | 106 (65.8) | 8 (42.1) | |||
| Greater than 1 | 66 (36.7) | 55 (34.2) | 11 (57.9) | |||
| Total | 180 | 161 | 19 | .042‡ | ||
| B-cell precursor ALL | ||||||
| Less than or equal to 1* | 206 (66.9) | 198 (69.2) | 8 (36.4) | |||
| Greater than 1 | 102 (33.1) | 88 (30.8) | 14 (63.6) | |||
| Total | 308 | 286 | 22 | .002‡ | ||