Patient characteristics
. | Control, n = 13 (min, median, max) . | SCD off hydroxyurea, n = 17 (min, median, max) . | SCD on hydroxyurea, n = 10 (min, median, max) . | P* . | P† . | P‡ . | P§ . |
|---|---|---|---|---|---|---|---|
| Age, in years, mean | 31 (21, 32, 43) | 33 (21, 34, 47) | 35 (21, 37, 47) | .62 | .09 | .47 | .54 |
| Gender, female/male | 6/7 | 8/9 | 6/4 | — | — | — | — |
| Hemoglobin, %, mean | 14.0 (11.0, 14.7, 15.9) | 8.5 (5.9, 8.6, 12.3) | 10.4 (8.8, 10.0, 12.6) | < 10-8 | < 10-9 | < 10-5 | .007 |
| Hematocrit, %, mean | 42.0 (34.0, 43.0, 47.0) | 24.6(15.2, 25.0, 34.7) | 29.4 (24.5, 28.1, 36.3) | < 10-9 | < 10-9 | < 10-6 | .019 |
| Reticulocytes, K/μm3, mean | 76 (42, 67, 137) | 404 (206, 403, 702) | 184 (74, 91, 264) | < 10-6 | < 10-5 | < .0004 | .0007 |
| Mean corpuscular volume, μm3, mean | 87 (66, 90, 95) | 84 (57, 85, 100) | 108 (100, 107, 119) | .035 | .31 | < 10-6 | .02 |
| Platetlet count, K/μm3, mean | 236 (200, 238, 290) | 331 (105, 376, 519) | 358 (251, 392, 450) | < 10-4 | .016 | .0016 | .45 |
| Total bilirubin, mg/dL, mean | 0.5 (0.3, 0.5, 1.0) | 3.5 (1.3, 3.5, 5.7) | 2.2 (0.8, 1.9, 4.5) | < 10-8 | < 10-7 | .002 | .01 |
| LDH, mg/dL, mean | 165 (66, 175, 217) | 359 (246, 360, 461) | 348 (201, 337, 589) | < 10-9 | < 10-9 | .003 | .9 |
| Fetal hemoglobin, d/dL, mean | 0.3 (0, 0, 1.2) | 5.6 (0.6, 4.0, 14.6) | 17.0 (0.35, 18.0, 25.3) | < 10-5 | < 10-4 | < .0004 | .001 |
| Creatinine, mg/dL, mean | 0.9 (0.8, 0.9, 1.2) | 0.6 (0.4, 0.6, 0.9) | 0.6 (0.3, 0.6, 1.2) | < 10-5 | < 10-6 | < .002 | 1 |
| Standard WBC differential counts | |||||||
| White blood cells count, K/μm3, mean | 6.2 (3.5, 6, 9.2) | 11.0 (6.4, 10.4, 19.4) | 7.6 (4.4, 7.2, 15.2) | < .002 | .0008 | .2 | .03 |
| Neutrophil % | 55.8 (37.0, 54.0, 70.0) | 55.0 (40.1, 53.8, 74) | 48.9 (35.5, 47.5, 70.3) | .39 | .7 | .1 | .2 |
| Lymphhocyte % | 32.2 (20.5, 33.0, 52.0) | 29.4 (13.9, 29.7, 43.1) | 38.4 (18.4, 40.0, 58.6) | .89 | .5 | .2 | .07 |
| Monocyte % | 7.7 (3.0, 7.0, 11.5) | 10.1 (4.0, 9.0, 19.7) | 9.3 (5.6, 8.8, 13.8) | .028 | .08 | .2 | .6 |
| Eosinophil % | 2.6 (1.1, 2, 5.5) | 4.2 (0, 3.0, 14.7) | 2.7 (0.4, 1.3, 7.2) | .19 | .08 | .9 | .2 |
| Basophil % | 0.6 (0, 0.5, 1.3) | 0.8 (0, 0.7, 2.6) | 1.0 (0.2, 1.0, 2.2) | .17 | .9 | .5 | .5 |
. | Control, n = 13 (min, median, max) . | SCD off hydroxyurea, n = 17 (min, median, max) . | SCD on hydroxyurea, n = 10 (min, median, max) . | P* . | P† . | P‡ . | P§ . |
|---|---|---|---|---|---|---|---|
| Age, in years, mean | 31 (21, 32, 43) | 33 (21, 34, 47) | 35 (21, 37, 47) | .62 | .09 | .47 | .54 |
| Gender, female/male | 6/7 | 8/9 | 6/4 | — | — | — | — |
| Hemoglobin, %, mean | 14.0 (11.0, 14.7, 15.9) | 8.5 (5.9, 8.6, 12.3) | 10.4 (8.8, 10.0, 12.6) | < 10-8 | < 10-9 | < 10-5 | .007 |
| Hematocrit, %, mean | 42.0 (34.0, 43.0, 47.0) | 24.6(15.2, 25.0, 34.7) | 29.4 (24.5, 28.1, 36.3) | < 10-9 | < 10-9 | < 10-6 | .019 |
| Reticulocytes, K/μm3, mean | 76 (42, 67, 137) | 404 (206, 403, 702) | 184 (74, 91, 264) | < 10-6 | < 10-5 | < .0004 | .0007 |
| Mean corpuscular volume, μm3, mean | 87 (66, 90, 95) | 84 (57, 85, 100) | 108 (100, 107, 119) | .035 | .31 | < 10-6 | .02 |
| Platetlet count, K/μm3, mean | 236 (200, 238, 290) | 331 (105, 376, 519) | 358 (251, 392, 450) | < 10-4 | .016 | .0016 | .45 |
| Total bilirubin, mg/dL, mean | 0.5 (0.3, 0.5, 1.0) | 3.5 (1.3, 3.5, 5.7) | 2.2 (0.8, 1.9, 4.5) | < 10-8 | < 10-7 | .002 | .01 |
| LDH, mg/dL, mean | 165 (66, 175, 217) | 359 (246, 360, 461) | 348 (201, 337, 589) | < 10-9 | < 10-9 | .003 | .9 |
| Fetal hemoglobin, d/dL, mean | 0.3 (0, 0, 1.2) | 5.6 (0.6, 4.0, 14.6) | 17.0 (0.35, 18.0, 25.3) | < 10-5 | < 10-4 | < .0004 | .001 |
| Creatinine, mg/dL, mean | 0.9 (0.8, 0.9, 1.2) | 0.6 (0.4, 0.6, 0.9) | 0.6 (0.3, 0.6, 1.2) | < 10-5 | < 10-6 | < .002 | 1 |
| Standard WBC differential counts | |||||||
| White blood cells count, K/μm3, mean | 6.2 (3.5, 6, 9.2) | 11.0 (6.4, 10.4, 19.4) | 7.6 (4.4, 7.2, 15.2) | < .002 | .0008 | .2 | .03 |
| Neutrophil % | 55.8 (37.0, 54.0, 70.0) | 55.0 (40.1, 53.8, 74) | 48.9 (35.5, 47.5, 70.3) | .39 | .7 | .1 | .2 |
| Lymphhocyte % | 32.2 (20.5, 33.0, 52.0) | 29.4 (13.9, 29.7, 43.1) | 38.4 (18.4, 40.0, 58.6) | .89 | .5 | .2 | .07 |
| Monocyte % | 7.7 (3.0, 7.0, 11.5) | 10.1 (4.0, 9.0, 19.7) | 9.3 (5.6, 8.8, 13.8) | .028 | .08 | .2 | .6 |
| Eosinophil % | 2.6 (1.1, 2, 5.5) | 4.2 (0, 3.0, 14.7) | 2.7 (0.4, 1.3, 7.2) | .19 | .08 | .9 | .2 |
| Basophil % | 0.6 (0, 0.5, 1.3) | 0.8 (0, 0.7, 2.6) | 1.0 (0.2, 1.0, 2.2) | .17 | .9 | .5 | .5 |
P value is for the comparison of sickle cell patients (on and off hydroxyurea) versus control subjects.
P value for the comparison of HbSS sickle cell patients off hydroxyurea versus control subjects.
P value for the comparison of HbSS sickle cell patients on hydroxyurea versus control subjects.
P value for the comparison of HbSS patients on hydroxyurea versus HbSS patients off hydroxyurea.