Bleeding symptoms in members of the family with QPD
. | % (proportion) responding with the symptom . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Symptom . | A . | U . | OR . | 95% CI . | Score . | |
| Blood relatives with bleeding problems | 100 (23/23) | 24 (24/98) | 137 | 13-1000 | Excluded | |
| Had bleeding problems that led to a change in lifestyle | 60 (12/20) | 0 (0/9) | α | 1.9-α | 1 | |
| Abundant bruises or bleeding | 57 (13/23) | 26 (27/104) | 3.7 | 1.3-11 | 1 | |
| Bruising | ||||||
| Without reason | 55 (12/22) | 34 (34/99) | 2.0 | 0.8-6.5 | — | |
| Disproportionate to trauma | 39 (9/23) | 12 (12/100) | 4.7 | 1.5-15 | 1 | |
| Noticed by other people | 4 (1/23) | 1 (1/99) | 4.5 | 0.1-170 | — | |
| Painful | 22 (5/23) | 6 (6/99) | 4.3 | 1.0-18 | — | |
| That lasts a long time | 22 (5/23) | 10 (10/99) | 2.5 | 0.6-9.2 | — | |
| That spreads toward feet or size of an orange or larger | 32 (7/23) | 0 (0/99) | α | 4.6-α | 1 | |
| Experienced deep cut(s) | 70 (16/23) | 59 (61/104) | 1.6 | 0.6-4.8 | — | |
| Bleeding with this cut continued for days | 56 (9/16) | 3 (2/60) | 37 | 5.6-320 | 1 | |
| Get nosebleeds | 57 (13/23) | 24 (25/103) | 4.0 | 1.4-12 | 1 | |
| Have had nosebleeds | ||||||
| Lasting longer than 15 min | 77 (10/13) | 56 (14/25) | 2.6 | 0.5-16 | — | |
| That required nasal packing | 15 (2/13) | 12 (3/25) | 1.3 | 0.1-12 | — | |
| That required cautery | 24 (3/13) | 24 (6/25) | 1.0 | 0.2-6.6 | — | |
| That required transfusion | 8 (1/13) | 0 (0/25) | α | 0.03-α | — | |
| That required hospitalization | 17 (2/12) | 0 (0/25) | α | 0.3-α | — | |
| Hematuria | 50 (11/22) | 12 (12/104) | 7.7 | 2.4-25 | 1 | |
| Joint bleeds | 43 (10/23) | 0 (0/104) | α | 7.4-α | 1 | |
| Had dental extractions | 74 (17/23) | 74 (77/104) | 1.0 | 0.3-3.1 | — | |
| With abnormal bleeding | 94 (16/17) | 35 (26/75) | 30 | 3.8-644 | 1 | |
| Bleeding for more than 24 h afterward | 94 (16/17) | 8 (6/72) | 176 | 18-4250 | 1 | |
| Gum problems | 14 (3/21) | 12 (13/104) | 1.2 | 0.2-5.1 | — | |
| Bleeding problems with surgery(ies) | 50 (9/18) | 9 (7/79) | 10 | 2.7-41 | 1 | |
| That required transfusions | 38 (5/13) | 3 (2/70) | 21 | 2.9-195 | * | |
| That required other treatments for bleeding | 38 (5/13) | 3 (2/71) | 22 | 2.9-198 | 1 | |
| Had a serious accident | 65 (15/23) | 38 (39/104) | 3.1 | 1.0-9.0 | — | |
| Bled excessively afterward | 86 (12/14) | 39 (15/38) | 9.2 | 1.6-70 | 1 | |
| Bleeding right away | 79 (11/14) | 57 (17/30) | 2.8 | 0.5-16 | — | |
| Bleeding started 12 h later | 8 (1/12) | 0 (0/30) | α | 0.04-α | — | |
| Needed to be hospitalized | 67 (10/15) | 26 (10/39) | 5.8 | 1.4-26 | 1 | |
| Became anemic after accident | 15 (2/13) | 7 (2/30) | 3.0 | 0.2-30 | — | |
| Needed transfusion after accident | 31 (4/13) | 7 (2/30) | 6.0 | 0.8-60 | — | |
| Developed wound infection | 8 (1/13) | 0 (0/30) | α | 0.03-α | — | |
| Problems healing after an injury | 26 (6/23) | 7 (7/104) | 4.9 | 1.3-19 | 1 | |
| History of transfusions | 52 (12/23) | 10 (10/100) | 9.8 | 3.1-32 | 1* | |
| Other treatments recommended for bleeding | 87 (20/23) | 2 (2/90) | 293 | 38-3370 | 1 | |
. | % (proportion) responding with the symptom . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Symptom . | A . | U . | OR . | 95% CI . | Score . | |
| Blood relatives with bleeding problems | 100 (23/23) | 24 (24/98) | 137 | 13-1000 | Excluded | |
| Had bleeding problems that led to a change in lifestyle | 60 (12/20) | 0 (0/9) | α | 1.9-α | 1 | |
| Abundant bruises or bleeding | 57 (13/23) | 26 (27/104) | 3.7 | 1.3-11 | 1 | |
| Bruising | ||||||
| Without reason | 55 (12/22) | 34 (34/99) | 2.0 | 0.8-6.5 | — | |
| Disproportionate to trauma | 39 (9/23) | 12 (12/100) | 4.7 | 1.5-15 | 1 | |
| Noticed by other people | 4 (1/23) | 1 (1/99) | 4.5 | 0.1-170 | — | |
| Painful | 22 (5/23) | 6 (6/99) | 4.3 | 1.0-18 | — | |
| That lasts a long time | 22 (5/23) | 10 (10/99) | 2.5 | 0.6-9.2 | — | |
| That spreads toward feet or size of an orange or larger | 32 (7/23) | 0 (0/99) | α | 4.6-α | 1 | |
| Experienced deep cut(s) | 70 (16/23) | 59 (61/104) | 1.6 | 0.6-4.8 | — | |
| Bleeding with this cut continued for days | 56 (9/16) | 3 (2/60) | 37 | 5.6-320 | 1 | |
| Get nosebleeds | 57 (13/23) | 24 (25/103) | 4.0 | 1.4-12 | 1 | |
| Have had nosebleeds | ||||||
| Lasting longer than 15 min | 77 (10/13) | 56 (14/25) | 2.6 | 0.5-16 | — | |
| That required nasal packing | 15 (2/13) | 12 (3/25) | 1.3 | 0.1-12 | — | |
| That required cautery | 24 (3/13) | 24 (6/25) | 1.0 | 0.2-6.6 | — | |
| That required transfusion | 8 (1/13) | 0 (0/25) | α | 0.03-α | — | |
| That required hospitalization | 17 (2/12) | 0 (0/25) | α | 0.3-α | — | |
| Hematuria | 50 (11/22) | 12 (12/104) | 7.7 | 2.4-25 | 1 | |
| Joint bleeds | 43 (10/23) | 0 (0/104) | α | 7.4-α | 1 | |
| Had dental extractions | 74 (17/23) | 74 (77/104) | 1.0 | 0.3-3.1 | — | |
| With abnormal bleeding | 94 (16/17) | 35 (26/75) | 30 | 3.8-644 | 1 | |
| Bleeding for more than 24 h afterward | 94 (16/17) | 8 (6/72) | 176 | 18-4250 | 1 | |
| Gum problems | 14 (3/21) | 12 (13/104) | 1.2 | 0.2-5.1 | — | |
| Bleeding problems with surgery(ies) | 50 (9/18) | 9 (7/79) | 10 | 2.7-41 | 1 | |
| That required transfusions | 38 (5/13) | 3 (2/70) | 21 | 2.9-195 | * | |
| That required other treatments for bleeding | 38 (5/13) | 3 (2/71) | 22 | 2.9-198 | 1 | |
| Had a serious accident | 65 (15/23) | 38 (39/104) | 3.1 | 1.0-9.0 | — | |
| Bled excessively afterward | 86 (12/14) | 39 (15/38) | 9.2 | 1.6-70 | 1 | |
| Bleeding right away | 79 (11/14) | 57 (17/30) | 2.8 | 0.5-16 | — | |
| Bleeding started 12 h later | 8 (1/12) | 0 (0/30) | α | 0.04-α | — | |
| Needed to be hospitalized | 67 (10/15) | 26 (10/39) | 5.8 | 1.4-26 | 1 | |
| Became anemic after accident | 15 (2/13) | 7 (2/30) | 3.0 | 0.2-30 | — | |
| Needed transfusion after accident | 31 (4/13) | 7 (2/30) | 6.0 | 0.8-60 | — | |
| Developed wound infection | 8 (1/13) | 0 (0/30) | α | 0.03-α | — | |
| Problems healing after an injury | 26 (6/23) | 7 (7/104) | 4.9 | 1.3-19 | 1 | |
| History of transfusions | 52 (12/23) | 10 (10/100) | 9.8 | 3.1-32 | 1* | |
| Other treatments recommended for bleeding | 87 (20/23) | 2 (2/90) | 293 | 38-3370 | 1 | |
Odds ratios (ORs) and 95% confidence intervals (CIs) compare affected (A) and unaffected (U) family members.
— indicates items not included in bleeding scores; α, OR estimated as infinite.
Overlapping queries, scored once as indicated.