Chromosomal regions with differential expression composing the HCL signature and relevant genes mapped to these regions
Chromosomal regions with differential expression* . | Some relevant genes involved in the biology of hematopoietic cells and oncogenesis† . |
|---|---|
| 1p31 ↓ /1q31 ↑ | —/RGS18, RGS1, RGS13, RGS2, CD45 |
| 2q22-q24 ↑ /2q24-q32.1 ↓ | ZFHX1B/HOXD |
| 3p24 ↓ /3p21-p23 ↓ /3p21 ↓ /3p14-p21 ↓ /3q13.3-q22 ↓ /3q26 ↓ | —/CCR4, PDCD6IP, ITGA9, CTNNB1/MST1R, RASSF1A, HYAL1-3/—/RYK, EPHB1/TRAIL, WIG1 |
| 4p16 ↓ /4q22-q24 ↑ /4q26-q27 ↑ | FGFR3, RGS12/TMSL4, NFKB1,PGD2‡/IL2, IL21,FGF2‡ |
| 5p14-p15.1 ↑ /5q14-q15 ↑ /5q23-q31 ↑ | —/—/PPIC‡, IL3,GM-CSF, IRF1, IL5, IL4, IL13, CDC25C, EGR1 |
| 6p21.2-p21.3 ↓ /6q14 ↑ /6q15-21 ↑ /6q25-q27 ↓ | DDR1, TNFA, LTA, LTB, MHC2, DAXX, BAK, ETV7, CDKN1A, PIM1/—/MAP3K7, EPHA7, FYN/ST8 |
| 7p14-p15 ↓ /7q31 ↑ | IL6, HOXA/MET |
| 8p21-p22 ↓ /8q13-q21.3 ↑ /8q22 ↓ /8q23 ↑ | TNFRSF10A-D/—/—/— |
| 9p21 ↑ /9q21-q22 ↑ | CDKN2A/B, TEK/ANXA1, NTRK2, SYK, ROR2, PTCH,PHF2‡ |
| 10p12-p13 ↓ /10q22 ↓ /10q24-q25 ↓ | —/—/PTEN, FAS, HOX11 |
| 11q23 ↓ | NCAM1, IL10RA, MLL,CXCR5‡ |
| 12p13 ↓ /12p11.2-p12 ↑ | CCND2, ETV6, p27/CAZ3, LRMP, KRAS1 |
| 13q31 ↑ | SPRY2‡, Y918‡ |
| 14q22-q24 ↓ | CDKN3, RGS6, TGFB3 |
| 15q21-q22 ↓ /15q24-q25 ↓ | B2M/CSK, KIP2, NTRK3 |
| 17p11.2-p13.1 ↓ /17q12-q21 ↓ /17q22-q24 ↓ | TP53, TNK1/ERBB2, CSF3, RARA, CDC6, TOP2A, CCR7, STAT3, STAT5, NME1/2/RGS9, PRKAR1A |
| 18q12-q21.1 ↑ | MAPK4, MADH4 |
| 19p13.2 ↑ /19q13.2-q13.3 ↓ /19q13.2-q13.3 ↑ | INSR, TYK2, CDC37, ILF3, ACP5 (TRAP), JUNB/AXL, TGFB1, KIAA1883, BAX, NSPL1‡, RRAS‡ |
| 20p12-p13 ↓ | PCNA |
| 21q21-q22 ↓ | IL10RB, AML1 |
| 22q12-q13.1 ↓ | NF2, OSM, LIF |
| Xq13.3-q21, ↑ /Xq25q26 ↑ | LAMR1, BTK/CD40L |
Chromosomal regions with differential expression* . | Some relevant genes involved in the biology of hematopoietic cells and oncogenesis† . |
|---|---|
| 1p31 ↓ /1q31 ↑ | —/RGS18, RGS1, RGS13, RGS2, CD45 |
| 2q22-q24 ↑ /2q24-q32.1 ↓ | ZFHX1B/HOXD |
| 3p24 ↓ /3p21-p23 ↓ /3p21 ↓ /3p14-p21 ↓ /3q13.3-q22 ↓ /3q26 ↓ | —/CCR4, PDCD6IP, ITGA9, CTNNB1/MST1R, RASSF1A, HYAL1-3/—/RYK, EPHB1/TRAIL, WIG1 |
| 4p16 ↓ /4q22-q24 ↑ /4q26-q27 ↑ | FGFR3, RGS12/TMSL4, NFKB1,PGD2‡/IL2, IL21,FGF2‡ |
| 5p14-p15.1 ↑ /5q14-q15 ↑ /5q23-q31 ↑ | —/—/PPIC‡, IL3,GM-CSF, IRF1, IL5, IL4, IL13, CDC25C, EGR1 |
| 6p21.2-p21.3 ↓ /6q14 ↑ /6q15-21 ↑ /6q25-q27 ↓ | DDR1, TNFA, LTA, LTB, MHC2, DAXX, BAK, ETV7, CDKN1A, PIM1/—/MAP3K7, EPHA7, FYN/ST8 |
| 7p14-p15 ↓ /7q31 ↑ | IL6, HOXA/MET |
| 8p21-p22 ↓ /8q13-q21.3 ↑ /8q22 ↓ /8q23 ↑ | TNFRSF10A-D/—/—/— |
| 9p21 ↑ /9q21-q22 ↑ | CDKN2A/B, TEK/ANXA1, NTRK2, SYK, ROR2, PTCH,PHF2‡ |
| 10p12-p13 ↓ /10q22 ↓ /10q24-q25 ↓ | —/—/PTEN, FAS, HOX11 |
| 11q23 ↓ | NCAM1, IL10RA, MLL,CXCR5‡ |
| 12p13 ↓ /12p11.2-p12 ↑ | CCND2, ETV6, p27/CAZ3, LRMP, KRAS1 |
| 13q31 ↑ | SPRY2‡, Y918‡ |
| 14q22-q24 ↓ | CDKN3, RGS6, TGFB3 |
| 15q21-q22 ↓ /15q24-q25 ↓ | B2M/CSK, KIP2, NTRK3 |
| 17p11.2-p13.1 ↓ /17q12-q21 ↓ /17q22-q24 ↓ | TP53, TNK1/ERBB2, CSF3, RARA, CDC6, TOP2A, CCR7, STAT3, STAT5, NME1/2/RGS9, PRKAR1A |
| 18q12-q21.1 ↑ | MAPK4, MADH4 |
| 19p13.2 ↑ /19q13.2-q13.3 ↓ /19q13.2-q13.3 ↑ | INSR, TYK2, CDC37, ILF3, ACP5 (TRAP), JUNB/AXL, TGFB1, KIAA1883, BAX, NSPL1‡, RRAS‡ |
| 20p12-p13 ↓ | PCNA |
| 21q21-q22 ↓ | IL10RB, AML1 |
| 22q12-q13.1 ↓ | NF2, OSM, LIF |
| Xq13.3-q21, ↑ /Xq25q26 ↑ | LAMR1, BTK/CD40L |
Regions with differential expression found in only one HCL pairing experiment are italicized; bold are regions found to be differentially expressed in at least 50% of analyzed cases.
Genes were selected from the human genome map (http://www.ensembl.org/); — indicates no relevant genes were identified in this region; bold are genes coding proteins with known underexpression/overexpression in HCL.
Genes found to be up- and down-regulated in HCL by Basso et al.20