The associations of IL-10 levels with allele frequency and genotype distribution of the IL-10−1082, IL-10−819, and IL-10−592 polymorphisms in 149 patients with DLBCL who provided samples available for ELISA at the time of initial presentation
. | IL-10 level less than 5 pg/mL . | IL-10 level 5 pg/mL or greater . |
|---|---|---|
| Allele frequency | ||
| IL-10−1082G | 0.45 | 0.53 |
| IL-10−1082A | 0.55 | 0.47 |
| IL-10−819C | 0.68 | 0.845 |
| IL-10−819T | 0.32* | 0.155 |
| IL-10−592C | 0.68 | 0.845 |
| IL-10−592A | 0.32* | 0.155 |
| Genotype distribution (%) | ||
| IL-10−1082GG | 26 (22) | 8 (25) |
| IL-10−1082GA | 54 (46) | 18 (56) |
| IL-10−1082AA | 37 (32) | 6 (19) |
| IL-10−819CC | 53 (45) | 23 (72)† |
| IL-10−819CT | 54 (46) | 8 (25) |
| IL-10−819TT | 10 (9) | 1 (3) |
| IL-10−592CC | 53 (45) | 23 (72)† |
| IL-10−592CA | 54 (46) | 8 (25) |
| IL-10−592AA | 10 (9) | 1 (3) |
. | IL-10 level less than 5 pg/mL . | IL-10 level 5 pg/mL or greater . |
|---|---|---|
| Allele frequency | ||
| IL-10−1082G | 0.45 | 0.53 |
| IL-10−1082A | 0.55 | 0.47 |
| IL-10−819C | 0.68 | 0.845 |
| IL-10−819T | 0.32* | 0.155 |
| IL-10−592C | 0.68 | 0.845 |
| IL-10−592A | 0.32* | 0.155 |
| Genotype distribution (%) | ||
| IL-10−1082GG | 26 (22) | 8 (25) |
| IL-10−1082GA | 54 (46) | 18 (56) |
| IL-10−1082AA | 37 (32) | 6 (19) |
| IL-10−819CC | 53 (45) | 23 (72)† |
| IL-10−819CT | 54 (46) | 8 (25) |
| IL-10−819TT | 10 (9) | 1 (3) |
| IL-10−592CC | 53 (45) | 23 (72)† |
| IL-10−592CA | 54 (46) | 8 (25) |
| IL-10−592AA | 10 (9) | 1 (3) |
Patient populations are as follows: IL-10 < 5 pg/mL, n = 117; IL-10 ≥ 5 pg/mL, n = 32.
P = .014, frequency of the IL-10−819T or IL-10−592A alleles in patients with DLBCL with elevated IL-10 serum levels (≥ 5 pg/mL) versus below its detection limit (< 5 pg/mL). P value refers to the χ2 test.
P = .014, frequency of the IL-10−819CC or IL-10−592CC genotypes in patients with DLBCL with elevated IL-10 serum levels (≥ 5 pg/mL) versus below its detection limit (< 5 pg/mL). P value refers to the χ2 test.