Table 1. Inhibition of VAP-1/SSAO and... | American Society of Hematology

Table 1.

Inhibition of VAP-1/SSAO and total MAO enzyme activity by hydroxylamine, semicarbazide, and BTT-2027

Compound	VAP-1/SSAO^*K_i, nM	tMAO†K_i, nM
Hydroxylamine	1.30 ± 0.30‡	42 000 ± 9 400
Semicarbazide	13 000 ± 3 700	> 88 000
BTT-2027	54 ± 4	2 300 ± 100

Compound	VAP-1/SSAO^*K_i, nM	tMAO†K_i, nM
Hydroxylamine	1.30 ± 0.30‡	42 000 ± 9 400
Semicarbazide	13 000 ± 3 700	> 88 000
BTT-2027	54 ± 4	2 300 ± 100

Recombinant VAP-1.

Liver homogenate.

Mean ± SEM of 3 to 11 similar experiments, each performed in duplicate.