Table 1.

Genes modulated in DMVECs after KSHV infection

Unigene cluster
Gene ID
Symbol
PowerBlot value
Name
Function
Group
Hs.82395   A40036  Fas  8.8   CD 95   Apoptosis   A  
Hs.89862   Q15628  TRADD  −1.5   TNFR1-associated death domain protein   Apoptosis   A  
Hs.381231  NP_001219 CASP8  Absent   Caspase 8   Apoptosis   A  
Hs.287797   P05556  ITGB1  1.8   Integrin beta 1   Cell adhesion   CA  
Hs.216381   A45973  Nexilin  −4.2   Nexilin   Cell adhesion   CA  
Hs.119537   A38219  KHDRBS1  3.0   Sre-associated in mitosis, 68 kDa   Mitosis   CD  
Hs.3849   AB045981  FKBP10  2.4   FK506-binding protein 10, 65 kDa   Cell proliferation   CD  
Hs.433496   Q9UN86  G3BP2  2.3   Ras-GAP   Mitogenesis   CD  
Hs. 104741  NP_060962 TOPK  −6.3   T-LAK cell-originated protein kinase   MAPKK   CD  
Hs.317432   P54687  BCAT1  −3.5   Branched chain aminotransferase 1   Cell proliferation   CD  
Hs.22868   JN0805  PTPN11  −2.9   Protein tyrosine phosphatase, nonreceptor type II   Protein-tyrosine phosphatase   CD  
Hs.181046   P51452  DUSP3  −2.8   Dual specificity phosphatase 3   Regulator of CDKs   CD  
Hs.211593   A45416  PRKCQ  −2.5   Protein kinase C theta   Cell proliferation   CD  
Hs.75770  NP_000312 RBI  −1.9   Retinoblastoma protein   Cell proliferation   CD  
Hs. 169449   P17252  PRKCA  Absent   Protein kinase C alpha   Cell proliferation   CD  
Hs.93183   S51797  VASP  3.0   Vasodilator-stimulated phosphoprotein   Cytoskeleton   CS  
Hs. 13405   Q9NQX3  GPHN  2.9   Gephyrin   Cytoskeleton   CS  
Hs.74034   Q03135  CAV1  2.6   Caveolin 1   Structural role in cavcolae   CS  
Hs. 171374  NP_055785 KIFAP3  2.5   Kinesin-associated protein 3   Microtubule organization   CS  
Hs.325474  NP_149129 CALD1  −2.6   L-Caldesmon   Cytoskeleton   CS  
Hs. 146409   A36382  CDC42  −2.4   Cell division cycle 42   Regulation of actin cytoskeleton   CS  
Hs.377973  NP_005563 LMNA  −1.9   Lamin A/C   Nuclear envelope formation   CS  
Hs. 180141  NP_068733 CFL2  −1.6   Cofilin 2   Actin-binding protein   CS  
Hs.84981   A32626  Ku80  1.8   Ku antigen 80 K chain   Double-stranded break repair   DR  
Hs. 192803   P23025  XPA  Absent   Xeroderma pigmentosum, complementation group A   Nucleotide excision repair   DR  
Hs.202833   P09601  HMOX1  4.2   Heme oxygenase (decycling) 1   Heme catabolism   M  
Hs. 171280   Q99714  HADH2  2.6   Hydroxyacyl-coenzyme A dehydrogenase, type II   Short-chain alcohol dehydrogenase   M  
Hs. 170222   A31311  SLC9A1  2.3   Solute carrier family 9, isoform 1   pH homeostasis   M  
Hs. 111039   JC1343  NMT1  2.1   N-myristoyltransferase, type 1   Myristylation   M  
Hs.6906  NP_005393 RALA  1.6   RAS-like protein A   GTP-binding protein   M  
Hs.1239   A30325  ANPEP  −3.5   Aminopeptidase M   Enkephalin processing   M  
Hs.122647  NP_004799 NMT-2  −2.2   N-myristoyltransferase, type 2   Myristylation   M  
Hs.9302   Q13371  PHLP  2.4   Phosducin-like protein   G-protein regulation   O  
Hs.153924   P53355  DAP kinase   1.9   Death-associated protein kinase I   IFN-gamma-associated cell death   O  
Hs.11866   O14925  TIMM23  2.7   Translocase of inner mitochondrial membrane 23   Mitochondrial protein translocation   PS  
Hs.16258  NP_570137 RAB24  2.1   RAB24   Vesicle sorting   PS  
Hs.84153   Q13561  DCTN2  1.9   Dynactin 2   Microtubule-based organelle transport   PS  
Hs.300631  NP_057610 GS15  1.8   Golgi SNARE, 15 kDa   Vesicle sorting   PS  
Hs.75410   P11021  HSPA5  1.6   Heat shock 70 kDa protein 5   Prevents aggregation   PS  
Hs.12797   O60231  DDX16  3.0   DEAH-box protein 16   Helicase   T  
Hs.96055   Q01094  E2F1  1.8   E2F transcription factor I   Transcription repressor   T  
Hs.408442   O14901  TIEG2  −5.7   TGFB inducible early growth response 2   Transcription repressor   T  
Hs.21486   P42224  STAT1  −2.6   Signal transducer and activator of transcription 1   Interferon-induced transcription   T  
Hs.146355  NP_009297 ABL1  2.6   Abelson murine leukemia viral oncogene homolog I   Oncogenesis   TG  
Hs.41714  NP_004314 BAG-1  2.4   Bcl-2-associated athanogene-1   Oncogenesis   TG  
Hs.1345   A33166  MCC  2   Mutated in colorectal cancer   Tumor suppressor   TG  
Hs.343475   ILYW_F  CTSD  1.7   Cathepsin D   Endopeptidase; estrogen inducible   TG  
Hs.226795   14GS_B  GSTP1  1.5   Glutathione S-transferase pi   Oncogenesis   TG  
Hs.58169  NP_006092 HEC  −3.0   Highly expressed in cancer   Oncogenesis   TG  
Hs.82483   Q15796  Smad 2/3  −2.1   Mothers against decapentaplegic homolog 2   Tumor suppressor   TG  
Hs.77183   P10398  ARAF1  Absent   A-Raf protooncogene   Oncogenesis   TG  
Hs.118796
 		NP_001146
 		ANXA6
 		 −4.9
 		 Annexin A6
 		 Unknown
 		 U
 
Unigene cluster
Gene ID
Symbol
PowerBlot value
Name
Function
Group
Hs.82395   A40036  Fas  8.8   CD 95   Apoptosis   A  
Hs.89862   Q15628  TRADD  −1.5   TNFR1-associated death domain protein   Apoptosis   A  
Hs.381231  NP_001219 CASP8  Absent   Caspase 8   Apoptosis   A  
Hs.287797   P05556  ITGB1  1.8   Integrin beta 1   Cell adhesion   CA  
Hs.216381   A45973  Nexilin  −4.2   Nexilin   Cell adhesion   CA  
Hs.119537   A38219  KHDRBS1  3.0   Sre-associated in mitosis, 68 kDa   Mitosis   CD  
Hs.3849   AB045981  FKBP10  2.4   FK506-binding protein 10, 65 kDa   Cell proliferation   CD  
Hs.433496   Q9UN86  G3BP2  2.3   Ras-GAP   Mitogenesis   CD  
Hs. 104741  NP_060962 TOPK  −6.3   T-LAK cell-originated protein kinase   MAPKK   CD  
Hs.317432   P54687  BCAT1  −3.5   Branched chain aminotransferase 1   Cell proliferation   CD  
Hs.22868   JN0805  PTPN11  −2.9   Protein tyrosine phosphatase, nonreceptor type II   Protein-tyrosine phosphatase   CD  
Hs.181046   P51452  DUSP3  −2.8   Dual specificity phosphatase 3   Regulator of CDKs   CD  
Hs.211593   A45416  PRKCQ  −2.5   Protein kinase C theta   Cell proliferation   CD  
Hs.75770  NP_000312 RBI  −1.9   Retinoblastoma protein   Cell proliferation   CD  
Hs. 169449   P17252  PRKCA  Absent   Protein kinase C alpha   Cell proliferation   CD  
Hs.93183   S51797  VASP  3.0   Vasodilator-stimulated phosphoprotein   Cytoskeleton   CS  
Hs. 13405   Q9NQX3  GPHN  2.9   Gephyrin   Cytoskeleton   CS  
Hs.74034   Q03135  CAV1  2.6   Caveolin 1   Structural role in cavcolae   CS  
Hs. 171374  NP_055785 KIFAP3  2.5   Kinesin-associated protein 3   Microtubule organization   CS  
Hs.325474  NP_149129 CALD1  −2.6   L-Caldesmon   Cytoskeleton   CS  
Hs. 146409   A36382  CDC42  −2.4   Cell division cycle 42   Regulation of actin cytoskeleton   CS  
Hs.377973  NP_005563 LMNA  −1.9   Lamin A/C   Nuclear envelope formation   CS  
Hs. 180141  NP_068733 CFL2  −1.6   Cofilin 2   Actin-binding protein   CS  
Hs.84981   A32626  Ku80  1.8   Ku antigen 80 K chain   Double-stranded break repair   DR  
Hs. 192803   P23025  XPA  Absent   Xeroderma pigmentosum, complementation group A   Nucleotide excision repair   DR  
Hs.202833   P09601  HMOX1  4.2   Heme oxygenase (decycling) 1   Heme catabolism   M  
Hs. 171280   Q99714  HADH2  2.6   Hydroxyacyl-coenzyme A dehydrogenase, type II   Short-chain alcohol dehydrogenase   M  
Hs. 170222   A31311  SLC9A1  2.3   Solute carrier family 9, isoform 1   pH homeostasis   M  
Hs. 111039   JC1343  NMT1  2.1   N-myristoyltransferase, type 1   Myristylation   M  
Hs.6906  NP_005393 RALA  1.6   RAS-like protein A   GTP-binding protein   M  
Hs.1239   A30325  ANPEP  −3.5   Aminopeptidase M   Enkephalin processing   M  
Hs.122647  NP_004799 NMT-2  −2.2   N-myristoyltransferase, type 2   Myristylation   M  
Hs.9302   Q13371  PHLP  2.4   Phosducin-like protein   G-protein regulation   O  
Hs.153924   P53355  DAP kinase   1.9   Death-associated protein kinase I   IFN-gamma-associated cell death   O  
Hs.11866   O14925  TIMM23  2.7   Translocase of inner mitochondrial membrane 23   Mitochondrial protein translocation   PS  
Hs.16258  NP_570137 RAB24  2.1   RAB24   Vesicle sorting   PS  
Hs.84153   Q13561  DCTN2  1.9   Dynactin 2   Microtubule-based organelle transport   PS  
Hs.300631  NP_057610 GS15  1.8   Golgi SNARE, 15 kDa   Vesicle sorting   PS  
Hs.75410   P11021  HSPA5  1.6   Heat shock 70 kDa protein 5   Prevents aggregation   PS  
Hs.12797   O60231  DDX16  3.0   DEAH-box protein 16   Helicase   T  
Hs.96055   Q01094  E2F1  1.8   E2F transcription factor I   Transcription repressor   T  
Hs.408442   O14901  TIEG2  −5.7   TGFB inducible early growth response 2   Transcription repressor   T  
Hs.21486   P42224  STAT1  −2.6   Signal transducer and activator of transcription 1   Interferon-induced transcription   T  
Hs.146355  NP_009297 ABL1  2.6   Abelson murine leukemia viral oncogene homolog I   Oncogenesis   TG  
Hs.41714  NP_004314 BAG-1  2.4   Bcl-2-associated athanogene-1   Oncogenesis   TG  
Hs.1345   A33166  MCC  2   Mutated in colorectal cancer   Tumor suppressor   TG  
Hs.343475   ILYW_F  CTSD  1.7   Cathepsin D   Endopeptidase; estrogen inducible   TG  
Hs.226795   14GS_B  GSTP1  1.5   Glutathione S-transferase pi   Oncogenesis   TG  
Hs.58169  NP_006092 HEC  −3.0   Highly expressed in cancer   Oncogenesis   TG  
Hs.82483   Q15796  Smad 2/3  −2.1   Mothers against decapentaplegic homolog 2   Tumor suppressor   TG  
Hs.77183   P10398  ARAF1  Absent   A-Raf protooncogene   Oncogenesis   TG  
Hs.118796
 		NP_001146
 		ANXA6
 		 −4.9
 		 Annexin A6
 		 Unknown
 		 U
 

A indicates apoptosis; TNFR1, tumor necrosis factor receptor 1; absent, protein present in mock-infected cells but not in KSHV-infected cells (fold change cannot be called); CA, cell adhesion; CD, cell division; FK506, tacrolimus; GAP, GTPase-activating protein; T-LAK, lymphokine-activated killer cells with T-cell phenotype; MAPKK, mitogen-activated protein kinase kinase; CS, cell shape; DR, DNA repair; M, metabolism; GTP, guanosine 5′-triphosphate; O, other; IFN, interferon; PS, protein sorting; T, transcription; TGFB, transforming growth factor beta; TG, tumorigenesis; and U, unknown.

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