Shared epitopes of HNE and PRO3 revealed by cross-recognition of HNE- and PRO3-specific T cells
. | HNE-primed CD3 . | . | PRO3-primed CD3 . | . | ||
|---|---|---|---|---|---|---|
. | 20:1 E/T ratio . | 5:1 E/T ratio . | 20:1 E/T ratio . | 5:1 E/T ratio . | ||
| HNE/Mo, % | 10.8 | 1.6 | 19.2* | 4.3* | ||
| PRO3/Mo, % | 14.1* | 1.7* | 5.6 | 2.3 | ||
| Mo, % | 0 | 0 | 0 | 0 | ||
. | HNE-primed CD3 . | . | PRO3-primed CD3 . | . | ||
|---|---|---|---|---|---|---|
. | 20:1 E/T ratio . | 5:1 E/T ratio . | 20:1 E/T ratio . | 5:1 E/T ratio . | ||
| HNE/Mo, % | 10.8 | 1.6 | 19.2* | 4.3* | ||
| PRO3/Mo, % | 14.1* | 1.7* | 5.6 | 2.3 | ||
| Mo, % | 0 | 0 | 0 | 0 | ||
Lymphocytes from donor 12 were stimulated 3 times with HNE- or PRO3-loaded monocytes, and their cytotoxicity against HNE- or PRO3-loaded targets was measured in the Calcein-am release assay.
Significant responses.