Morphometric evaluation of bone marrow angiogenesis in 98 patients with Ph+/BCR-ABL+ CML showing absolute and relative changes (difference between pretreatment and posttreatment values) in individuals following first-line therapy in sequential biopsies
. | Imatinib . | IFN . | HU . | IFN + HU . |
|---|---|---|---|---|
| No. patients | 14 | 34 | 31 | 19 |
| Median biopsy interval, mo | 12 | 10 | 16 | 11 |
| Absolute changes during therapy, mean ± SD | ||||
| Fiber density, i × 102 per mm2 hematopoiesis | −13.5 ± 13.4* | +30.7 ± 34.0 | +0.1 ± 27.1 | +31.1 ± 53.4 |
| MVD, per mm2 hematopoiesis | −32.7 ± 52.5* | +17.8 ± 52.2 | −2.6 ± 51.9 | +17.4 ± 62.0 |
| MVA, μm2 | +48.6 ± 204.7* | −0.4 ± 78.9 | +31.7 ± 144 | +7.8 ± 138.8 |
| Tortuosity of microvessels, maximal length in μm | +0.8 ± 9.8 | −0.1 ± 2.4 | +0.5 ± 3.7 | −0.6 ± 3.6 |
| Aspect ratio | +0.17 ± 0.87 | −0.14 ± 0.43 | −0.67 ± 0.52 | −0.47 ± 0.47 |
| Form factor, circular deviation | −0.18 ± 0.06 | −0.02 ± 0.04 | +0.01 ± 0.05 | +0.04 ± 0.06 |
| Relative changes during therapy | ||||
| Fiber density, % | ||||
| Decrease/stable | 78.6* | 23.4 | 50.3 | 30.4 |
| Increase | 21.4 | 76.6 | 49.7 | 69.6 |
| MVD, % | ||||
| Decrease/stable | 78.6* | 37.5 | 55.2 | 33.3 |
| Increase | 21.4 | 62.5 | 44.8 | 66.7 |
. | Imatinib . | IFN . | HU . | IFN + HU . |
|---|---|---|---|---|
| No. patients | 14 | 34 | 31 | 19 |
| Median biopsy interval, mo | 12 | 10 | 16 | 11 |
| Absolute changes during therapy, mean ± SD | ||||
| Fiber density, i × 102 per mm2 hematopoiesis | −13.5 ± 13.4* | +30.7 ± 34.0 | +0.1 ± 27.1 | +31.1 ± 53.4 |
| MVD, per mm2 hematopoiesis | −32.7 ± 52.5* | +17.8 ± 52.2 | −2.6 ± 51.9 | +17.4 ± 62.0 |
| MVA, μm2 | +48.6 ± 204.7* | −0.4 ± 78.9 | +31.7 ± 144 | +7.8 ± 138.8 |
| Tortuosity of microvessels, maximal length in μm | +0.8 ± 9.8 | −0.1 ± 2.4 | +0.5 ± 3.7 | −0.6 ± 3.6 |
| Aspect ratio | +0.17 ± 0.87 | −0.14 ± 0.43 | −0.67 ± 0.52 | −0.47 ± 0.47 |
| Form factor, circular deviation | −0.18 ± 0.06 | −0.02 ± 0.04 | +0.01 ± 0.05 | +0.04 ± 0.06 |
| Relative changes during therapy | ||||
| Fiber density, % | ||||
| Decrease/stable | 78.6* | 23.4 | 50.3 | 30.4 |
| Increase | 21.4 | 76.6 | 49.7 | 69.6 |
| MVD, % | ||||
| Decrease/stable | 78.6* | 37.5 | 55.2 | 33.3 |
| Increase | 21.4 | 62.5 | 44.8 | 66.7 |
SD indicates standard deviation; MVD, microvessel density; MVA, microvessel area.
Imatinib versus IFN, P < .01 (Mann-Whitney U test).