TNF-α-mediated down-regulation of selected genes in endothelial cells
Genes down-regulated by TNF-α . | Accession no. . | Fold-change or grade of expression over background in wild-type HUVECs* . | P . | Inhibition dependent on IKK2/NF-κB, % . | Inhibition dependent on p38 MAP kinase, % . |
|---|---|---|---|---|---|
| Cell-surface receptors | |||||
| Coxsackie virus and adenovirus receptor† | NM_001338.1 | −2.8 | < .001 | 100.0 | No |
| Signaling/transcription | |||||
| Inhibitor of DNA binding 1, dominant-negative helix-loop-helix protein | D13889 | −3.6 | < .001 | ND | No |
| SRY-box 18‡ | NM_018419.1 | −3.2 | < .001 | 100 | No |
| CBP/p300-interacting transactivator 2§ | AF109161.1 | −2.9 | < .001 | ND | |
| v-yes-1 Yamaguchi sarcoma viral-related oncogene homolog | AI356412 | −2.8 | < .005 | 100.0 | No |
| Inflammation/immune response | |||||
| DnaJ homolog, subfamily B; member 4∥ | BG252490 | −4.0 | < .001 | 100.0 | No |
| Apoptosis/cell proliferation/cell cycle | |||||
| Cyclin E2 | NM_004702.1 | −2.7 | < .001 | ND | No |
| Cyclin A1 | NM_003914.1 | −2.5 | < .001 | ND | No |
Genes down-regulated by TNF-α . | Accession no. . | Fold-change or grade of expression over background in wild-type HUVECs* . | P . | Inhibition dependent on IKK2/NF-κB, % . | Inhibition dependent on p38 MAP kinase, % . |
|---|---|---|---|---|---|
| Cell-surface receptors | |||||
| Coxsackie virus and adenovirus receptor† | NM_001338.1 | −2.8 | < .001 | 100.0 | No |
| Signaling/transcription | |||||
| Inhibitor of DNA binding 1, dominant-negative helix-loop-helix protein | D13889 | −3.6 | < .001 | ND | No |
| SRY-box 18‡ | NM_018419.1 | −3.2 | < .001 | 100 | No |
| CBP/p300-interacting transactivator 2§ | AF109161.1 | −2.9 | < .001 | ND | |
| v-yes-1 Yamaguchi sarcoma viral-related oncogene homolog | AI356412 | −2.8 | < .005 | 100.0 | No |
| Inflammation/immune response | |||||
| DnaJ homolog, subfamily B; member 4∥ | BG252490 | −4.0 | < .001 | 100.0 | No |
| Apoptosis/cell proliferation/cell cycle | |||||
| Cyclin E2 | NM_004702.1 | −2.7 | < .001 | ND | No |
| Cyclin A1 | NM_003914.1 | −2.5 | < .001 | ND | No |
All data shown represent observations that have so far not been reported in literature.
ND indicates not detectable, since our strict statistical criteria do not appraise the respective gene transcripts in empty expression vector-infected HUVECs as TNF-α inducible.
For details, see “Materials and methods.”
CAR.
Sex-determining region Y.
MSG-related protein 1; MRG1 protein.
HSP40.