Table 5.

Univariate and multivariate Cox regression analysis of risk factors

Univariate analysis
Multivariate analysis
Risk factor
HR
95% CI
P
HR
95% CI
P
Overall survival       
FLAG arm   0.83   0.56-1.22   NS   0.91   0.60-1.38   NS  
Female   1.05   0.70-1.58   NS   1.14   0.74-1.75   NS  
Age, y   1.03   0.99-1.07   NS   1.04   1.01-1.07   .014  
AML diagnosis   0.88   0.56-1.38   NS   0.90   0.53-1.52   NS  
Log platelet count   0.66   0.52-0.84   <.001   0.66   0.51-0.86   .002  
Log WBC count   1.21   1.04-1.40   .01   1.21   0.99-1.49   NS  
Bilirubin level   1.05   1.02-1.09   .005   1.07   1.03-1.12   .001  
Log ANC   1.10   0.98-1.25   NS   0.99   0.83-1.18   NS  
Cytopenias, no.   1.09   0.85-1.40   NS   0.85   0.61-1.17   NS  
Poor cytogenetic risk   2.33   1.47-3.67   <.001   2.82   1.73-4.60   <.001  
Event-free survival       
FLAG arm   0.87   0.60-1.25   NS   0.97   0.66-1.42   NS  
Female   0.98   0.67-1.44   NS   1.13   0.76-1.70   NS  
Age, y   1.03   1.00-1.06   NS   1.04   1.01-1.07   .004  
AML diagnosis   0.62   0.41-0.94   .024   0.57   0.35-0.92   .021  
Log platelet count   0.74   0.60-0.91   .004   0.77   0.61-0.98   .033  
Log WBC count   1.14   1.00-1.31   NS   1.08   0.89-1.30   NS  
Bilirubin level   1.06   1.02-1.09   .004   1.06   1.02-1.11   .006  
Log ANC   1.09   0.98-1.22   NS   1.06   0.89-1.26   NS  
Cytopenias, no.   1.11   0.88-1.39   NS   0.99   0.73-1.34   NS  
Poor cytogenetic risk   2.33   1.49-3.64   <.001   2.47   1.55-3.93   <.001  
Disease-free survival       
FLAG arm   0.86   0.54-1.36   NS   0.87   0.53-1.42   NS  
AML diagnosis   0.73   0.45-1.20   NS   0.74   0.44-1.23   NS  
Log platelet count   0.81   0.62-1.07   NS   1.00   0.76-1.32   NS  
Bilirubin level   1.07   1.02-1.12   .009   1.04   0.98-1.10   NS  
Poor cytogenetic risk
 		 3.66
 		 2.03-6.57
 		 <.001
 		 3.24
 		 1.71-6.14
 		 <.001
 
Univariate analysis
Multivariate analysis
Risk factor
HR
95% CI
P
HR
95% CI
P
Overall survival       
FLAG arm   0.83   0.56-1.22   NS   0.91   0.60-1.38   NS  
Female   1.05   0.70-1.58   NS   1.14   0.74-1.75   NS  
Age, y   1.03   0.99-1.07   NS   1.04   1.01-1.07   .014  
AML diagnosis   0.88   0.56-1.38   NS   0.90   0.53-1.52   NS  
Log platelet count   0.66   0.52-0.84   <.001   0.66   0.51-0.86   .002  
Log WBC count   1.21   1.04-1.40   .01   1.21   0.99-1.49   NS  
Bilirubin level   1.05   1.02-1.09   .005   1.07   1.03-1.12   .001  
Log ANC   1.10   0.98-1.25   NS   0.99   0.83-1.18   NS  
Cytopenias, no.   1.09   0.85-1.40   NS   0.85   0.61-1.17   NS  
Poor cytogenetic risk   2.33   1.47-3.67   <.001   2.82   1.73-4.60   <.001  
Event-free survival       
FLAG arm   0.87   0.60-1.25   NS   0.97   0.66-1.42   NS  
Female   0.98   0.67-1.44   NS   1.13   0.76-1.70   NS  
Age, y   1.03   1.00-1.06   NS   1.04   1.01-1.07   .004  
AML diagnosis   0.62   0.41-0.94   .024   0.57   0.35-0.92   .021  
Log platelet count   0.74   0.60-0.91   .004   0.77   0.61-0.98   .033  
Log WBC count   1.14   1.00-1.31   NS   1.08   0.89-1.30   NS  
Bilirubin level   1.06   1.02-1.09   .004   1.06   1.02-1.11   .006  
Log ANC   1.09   0.98-1.22   NS   1.06   0.89-1.26   NS  
Cytopenias, no.   1.11   0.88-1.39   NS   0.99   0.73-1.34   NS  
Poor cytogenetic risk   2.33   1.49-3.64   <.001   2.47   1.55-3.93   <.001  
Disease-free survival       
FLAG arm   0.86   0.54-1.36   NS   0.87   0.53-1.42   NS  
AML diagnosis   0.73   0.45-1.20   NS   0.74   0.44-1.23   NS  
Log platelet count   0.81   0.62-1.07   NS   1.00   0.76-1.32   NS  
Bilirubin level   1.07   1.02-1.12   .009   1.04   0.98-1.10   NS  
Poor cytogenetic risk
 		 3.66
 		 2.03-6.57
 		 <.001
 		 3.24
 		 1.71-6.14
 		 <.001
 

Abbreviations are explained in the caption for Table 4. HR indicates hazard ratio.

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