Absolute cell numbers in different hematopoietic compartments of wild-type, Hoxa7−/−, and Hoxa9−/− mice
. | Wild-type . | Hoxa7−/− . | Hoxa9−/− . |
|---|---|---|---|
| HSC and MPP count, × 103 | 32 ± 13 | 36 ± 11 | 34 ± 21 |
| CLP count, ×103 | 35 ± 11 | 37 ± 10 | 8 ± 2.4† |
| CMP count, ×103 | 108 ± 21 | 93 ± 23 | 33 ± 12† |
| GMP count, ×103 | 190 ± 33 | 210 ± 45 | 69 ± 31† |
| MEP count, ×103 | 256 ± 55 | 140 ± 42* | 280 ± 135 |
| Total Pro-B count, ×106 | 1.9 ± 0.39 | 2.5 ± 0.58 | 1.2 ± 0.45* |
| Pro-B (Fr. A) count, ×103 | 480 ± 170 | 640 ± 185 | 435 ± 135 |
| Pro-B (Fr. B-C) count, ×106 | 1.4 ± 0.31 | 1.8 ± 0.45 | 0.71 ± 0.21† |
| Pre-B count, ×106 | 13.8 ± 1.5 | 15.3 ± 2.9 | 3.4 ± 2.1† |
| Pro-T1 count, ×103 | 11.3 ± 0.33 | 8.3 ± 1.7 | 0.72 ± 0.13† |
| Pro-T2 count, ×103 | 10.9 ± 0.31 | 7.2 ± 2.3 | 0.31 ± 0.064† |
| CD4−/CD8−/TCRβ− count, ×106 | 0.21 ± 0.032 | 0.29 ± 0.065 | ND |
| CD4−/CD8− count, ×106 | 0.3 ± 0.045 | 0.4 ± 0.12 | ND |
| CD4+/CD8+ count, ×106 | 9.8 ± 1.2 | 6.8 ± 2.3 | ND |
| CD4+/CD8− count, ×106 | 0.73 ± 0.12 | 0.8 ± 0.34 | ND |
| CD4−/CD8+ count, ×106 | 0.36 ± 0.08 | 0.26 ± 0.036 | ND |
. | Wild-type . | Hoxa7−/− . | Hoxa9−/− . |
|---|---|---|---|
| HSC and MPP count, × 103 | 32 ± 13 | 36 ± 11 | 34 ± 21 |
| CLP count, ×103 | 35 ± 11 | 37 ± 10 | 8 ± 2.4† |
| CMP count, ×103 | 108 ± 21 | 93 ± 23 | 33 ± 12† |
| GMP count, ×103 | 190 ± 33 | 210 ± 45 | 69 ± 31† |
| MEP count, ×103 | 256 ± 55 | 140 ± 42* | 280 ± 135 |
| Total Pro-B count, ×106 | 1.9 ± 0.39 | 2.5 ± 0.58 | 1.2 ± 0.45* |
| Pro-B (Fr. A) count, ×103 | 480 ± 170 | 640 ± 185 | 435 ± 135 |
| Pro-B (Fr. B-C) count, ×106 | 1.4 ± 0.31 | 1.8 ± 0.45 | 0.71 ± 0.21† |
| Pre-B count, ×106 | 13.8 ± 1.5 | 15.3 ± 2.9 | 3.4 ± 2.1† |
| Pro-T1 count, ×103 | 11.3 ± 0.33 | 8.3 ± 1.7 | 0.72 ± 0.13† |
| Pro-T2 count, ×103 | 10.9 ± 0.31 | 7.2 ± 2.3 | 0.31 ± 0.064† |
| CD4−/CD8−/TCRβ− count, ×106 | 0.21 ± 0.032 | 0.29 ± 0.065 | ND |
| CD4−/CD8− count, ×106 | 0.3 ± 0.045 | 0.4 ± 0.12 | ND |
| CD4+/CD8+ count, ×106 | 9.8 ± 1.2 | 6.8 ± 2.3 | ND |
| CD4+/CD8− count, ×106 | 0.73 ± 0.12 | 0.8 ± 0.34 | ND |
| CD4−/CD8+ count, ×106 | 0.36 ± 0.08 | 0.26 ± 0.036 | ND |
Values are mean ± SD.
Fr. A indicates Hardy Fraction A; Fr. B-C, Hardy Fraction B-C; and ND, not determined.
*P<.01; †P<.001.