Table 1.

Comparison of IC50 and PF50 values derived from the growth inhibition curves

Drug
Drug alone IC50, nM*
Drug + NU7026 IC50, nM*
PF50†
mAMSA   32   1.6   19.2 ± 7.5  
Mitoxantrone   3   0.18   16.6 ± 6.6  
Etoposide   317   45   8.6 ± 1.0  
Doxorubicin   45   10   4.0 ± 0.38  
Daunorubicin   205   78   2.6 ± 0.11  
Idarubicin   9.5   5.4   1.7 ± 0.17  
Camptothecin   6.8   7.3   0.88 ± 0.17  
araC
 		 33
 		 66
 		 0.45 ± 0.29
 
Drug
Drug alone IC50, nM*
Drug + NU7026 IC50, nM*
PF50†
mAMSA   32   1.6   19.2 ± 7.5  
Mitoxantrone   3   0.18   16.6 ± 6.6  
Etoposide   317   45   8.6 ± 1.0  
Doxorubicin   45   10   4.0 ± 0.38  
Daunorubicin   205   78   2.6 ± 0.11  
Idarubicin   9.5   5.4   1.7 ± 0.17  
Camptothecin   6.8   7.3   0.88 ± 0.17  
araC
 		 33
 		 66
 		 0.45 ± 0.29
 
*

IC50 values are the means of at least 3 independent experiments.

†

All mean PF50 values (± SE) were calculated from the ratio of the individual IC50 values (eg, the concentration of drug that caused 50% growth inhibition divided by the concentration of drug that caused 50% growth inhibition in the presence of NU7026).

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