Average change in soluble KIT, SCF, and VEGF in patients with GISTs treated with imatinib mesylate
Factor . | Pretreatment . | 1 month on therapy* . | Average change, % . | 6 months on therapy† . | Average change, % . | P (change from pretreatment level)‡ . | P (responders vs nonresponders)‡ . |
|---|---|---|---|---|---|---|---|
| KIT | 292 AU/mL | 204 AU/mL | −31 | 132 AU/mL | −52 | .0012 | — |
| Responders | 298 AU/mL | 202 AU/mL | −35 | 140 AU/mL | −52 | — | .28 |
| Nonresponders | 258 AU/mL | 204 AU/mL | −17 | 113 AU/mL | −62 | — | — |
| SCF | 645 pg/mL | 770 pg/mL | 11 | 875 pg/mL | 33 | .0001 | — |
| Responders | 660 pg/mL | 740 pg/mL | 9 | 880 pg/mL | 33 | — | .18 |
| Nonresponders | 620 pg/mL | 780 pg/mL | 20 | 880 pg/mL | 23 | — | — |
| VEGF | 295 pg/mL | 180 pg/mL | −42 | 205 pg/mL | −31 | .14 | — |
| Responders | 320 pg/mL | 180 pg/mL | −45 | 220 pg/mL | −34 | — | .22 |
| Nonresponders | 160 pg/mL | 145 pg/mL | 0 | 185 pg/mL | −.9 | — | — |
Factor . | Pretreatment . | 1 month on therapy* . | Average change, % . | 6 months on therapy† . | Average change, % . | P (change from pretreatment level)‡ . | P (responders vs nonresponders)‡ . |
|---|---|---|---|---|---|---|---|
| KIT | 292 AU/mL | 204 AU/mL | −31 | 132 AU/mL | −52 | .0012 | — |
| Responders | 298 AU/mL | 202 AU/mL | −35 | 140 AU/mL | −52 | — | .28 |
| Nonresponders | 258 AU/mL | 204 AU/mL | −17 | 113 AU/mL | −62 | — | — |
| SCF | 645 pg/mL | 770 pg/mL | 11 | 875 pg/mL | 33 | .0001 | — |
| Responders | 660 pg/mL | 740 pg/mL | 9 | 880 pg/mL | 33 | — | .18 |
| Nonresponders | 620 pg/mL | 780 pg/mL | 20 | 880 pg/mL | 23 | — | — |
| VEGF | 295 pg/mL | 180 pg/mL | −42 | 205 pg/mL | −31 | .14 | — |
| Responders | 320 pg/mL | 180 pg/mL | −45 | 220 pg/mL | −34 | — | .22 |
| Nonresponders | 160 pg/mL | 145 pg/mL | 0 | 185 pg/mL | −.9 | — | — |
For each group (KIT, SCF, VEGF), study populations are as follows: responders, n = 57; and nonresponders, n = 9. The “baseline” and “on therapy” data are given as the medians observed; the average change is the median percentage of the change from the baseline value. —indicates not applicable.
N = 66.
N = 45.
Repeated measures ANOVA test.