Entry characteristics of both groups of patients
. | High dose; n = 201 . | Low dose; n = 206 . |
|---|---|---|
| HOVON-20, n (%) | 63 (31) | 67 (33) |
| MRC CML IV, n (%) | 15 (7) | 15 (7) |
| MRC CML V, n (%) | 123 (61) | 124 (60) |
| Age, y (range) | 60.3 (20-78) | 60.5 (20-81) |
| Female, % | 52 | 42 |
| Spleen palpable, n (%) | 114 (57) | 130 (63) |
| If yes, median in cm below Icm (range) | 7 (1-30) | 7 (1-25) |
| Hemoglobin level, g/L (range) | 116 (63-179) | 115 (66-174) |
| WBC count, × 109/L (range) | 146 (12-530) | 150 (11-650) |
| Basophils, % (range) | 4 (0-18) | 3 (0-29) |
| Eosinophils, % (range) | 2 (0-20) | 2 (0-16) |
| Blasts, % (range) | 1.2 (0-12) | 1.4 (0-16) |
| Platelet count, × 109/L (range) | 436 (78-2225) | 399 (63-1752) |
| Additional cytogenetic abnormalities, n | 3 | 5 |
| Sokal score lower than 0.8, % | 19 | 22 |
| Sokal score 0.8-1.2, % | 43 | 36 |
| Sokal score higher than 1.2, % | 38 | 41 |
| European risk score lower than 780, %* | 23 | 21 |
| European risk score 780-1480, % | 53 | 50 |
| European risk score higher than 1480, % | 13 | 21 |
. | High dose; n = 201 . | Low dose; n = 206 . |
|---|---|---|
| HOVON-20, n (%) | 63 (31) | 67 (33) |
| MRC CML IV, n (%) | 15 (7) | 15 (7) |
| MRC CML V, n (%) | 123 (61) | 124 (60) |
| Age, y (range) | 60.3 (20-78) | 60.5 (20-81) |
| Female, % | 52 | 42 |
| Spleen palpable, n (%) | 114 (57) | 130 (63) |
| If yes, median in cm below Icm (range) | 7 (1-30) | 7 (1-25) |
| Hemoglobin level, g/L (range) | 116 (63-179) | 115 (66-174) |
| WBC count, × 109/L (range) | 146 (12-530) | 150 (11-650) |
| Basophils, % (range) | 4 (0-18) | 3 (0-29) |
| Eosinophils, % (range) | 2 (0-20) | 2 (0-16) |
| Blasts, % (range) | 1.2 (0-12) | 1.4 (0-16) |
| Platelet count, × 109/L (range) | 436 (78-2225) | 399 (63-1752) |
| Additional cytogenetic abnormalities, n | 3 | 5 |
| Sokal score lower than 0.8, % | 19 | 22 |
| Sokal score 0.8-1.2, % | 43 | 36 |
| Sokal score higher than 1.2, % | 38 | 41 |
| European risk score lower than 780, %* | 23 | 21 |
| European risk score 780-1480, % | 53 | 50 |
| European risk score higher than 1480, % | 13 | 21 |
Data presented are median values for each category. Icm indicates left costal margin.
Percentages for European risk score do not sum up to 100% due to missing data.