Table 1. Summary of the domains cloned... | American Society of Hematology

Table 1.

Summary of the domains cloned for expression in E coli

	Protein fragment aa	MW, kDa, including thio/his	Region in ADAMTS13
I	Pro30-Arg74	21.3	propeptide
II	Arg386-Glu439	22	tsp1-1
III	Ala75-Glu439	55	cat/dis/tsp 1-1
IV	Lys440-Ala685	43.7	cys-rich/spacer
V	Trp686-Val1131	63.2	tsp 1/2-8
VI	Gly 1132-Thr1427	48.3	cub 1+2

	Protein fragment aa	MW, kDa, including thio/his	Region in ADAMTS13
I	Pro30-Arg74	21.3	propeptide
II	Arg386-Glu439	22	tsp1-1
III	Ala75-Glu439	55	cat/dis/tsp 1-1
IV	Lys440-Ala685	43.7	cys-rich/spacer
V	Trp686-Val1131	63.2	tsp 1/2-8
VI	Gly 1132-Thr1427	48.3	cub 1+2

Positions of the amino acids (aa's) spanning the selected domain(s) and calculated molecular weights (MWs) of the predicted his-tagged thioredoxin fusion protein are indicated.

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