Summary of mtDNA mutations of CD34 clones and single granulocytes
. | . | Heterogeneity (mutation) . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Poly C tract . | . | . | . | ||||||
| Specimens . | Assay no. (donor no.) . | Total rate, % (no.) . | Unique, % (no.) . | Substitution, % (no.) . | np 303-315, % (no.) . | np 16184-16189, % (no.) . | NC, % (no.) . | AA change, % (no.) . | ||||||
| CB CD34* | 580 (5) | 1.6 (9) | 1.2 (7) | 0.0 (0) | 0.0 (0) | 0.5 (3) | 0.7 (4) | — | ||||||
| Adult BM CD34* | 611 (6) | 24.9 (152) | 7.5 (46) | 10.5 (64) | 10.8 (66) | 1.1 (7) | 0.0 (0) | — | ||||||
| Adult PB CD34 | 594 (6) | 25.3 (150) | 5.1 (30) | 6.1 (36) | 15.3 (91) | 1.5 (9) | 0.0 (0) | — | ||||||
| Single granulocyte | 355 (6) | 29.0 (103) | 15.2 (54) | 11.8 (42) | 11.0 (39) | 3.4 (12) | 0.0 (0) | — | ||||||
| Adult BM CD34 | 285 (3) | 3.5 (10) | 3.5 (10) | 3.5 (10) | — | — | — | 63.6 (7/11†) | ||||||
| Adult PB CD34 | 284 (3) | 5.3 (15) | 4.2 (12) | 5.3 (15) | — | — | — | 50.0 (8/16†) | ||||||
| Subtotal | 569 (6) | 4.4 (25) | 3.9 (22) | 4.4 (25) | — | — | — | 55.6 (15/27†) | ||||||
. | . | Heterogeneity (mutation) . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Poly C tract . | . | . | . | ||||||
| Specimens . | Assay no. (donor no.) . | Total rate, % (no.) . | Unique, % (no.) . | Substitution, % (no.) . | np 303-315, % (no.) . | np 16184-16189, % (no.) . | NC, % (no.) . | AA change, % (no.) . | ||||||
| CB CD34* | 580 (5) | 1.6 (9) | 1.2 (7) | 0.0 (0) | 0.0 (0) | 0.5 (3) | 0.7 (4) | — | ||||||
| Adult BM CD34* | 611 (6) | 24.9 (152) | 7.5 (46) | 10.5 (64) | 10.8 (66) | 1.1 (7) | 0.0 (0) | — | ||||||
| Adult PB CD34 | 594 (6) | 25.3 (150) | 5.1 (30) | 6.1 (36) | 15.3 (91) | 1.5 (9) | 0.0 (0) | — | ||||||
| Single granulocyte | 355 (6) | 29.0 (103) | 15.2 (54) | 11.8 (42) | 11.0 (39) | 3.4 (12) | 0.0 (0) | — | ||||||
| Adult BM CD34 | 285 (3) | 3.5 (10) | 3.5 (10) | 3.5 (10) | — | — | — | 63.6 (7/11†) | ||||||
| Adult PB CD34 | 284 (3) | 5.3 (15) | 4.2 (12) | 5.3 (15) | — | — | — | 50.0 (8/16†) | ||||||
| Subtotal | 569 (6) | 4.4 (25) | 3.9 (22) | 4.4 (25) | — | — | — | 55.6 (15/27†) | ||||||