Mutational spectra of mtDNA control region in individual CD34 clones and single granulocytes
. | BM CD34 clones‡ . | . | . | . | PB CD34 clones . | . | . | . | Single granulocytes . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor (age, y/sex) . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | |||||||||
| . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | |||||||||
| 1 (47/F) | |||||||||||||||||||||
| Aggregate sequence | 85 | 30 (26.1) | 8 (7.0) | Aggregate sequence | 90 | 30 (25.0) | 5 (4.2) | Aggregate sequence | 39 | 12 (23.1) | 6 (11.5) | ||||||||||
| + 8CT6C§, 9CT6C§ | 22 | — | — | + 8CT6C§, 9CT6C§ | 23 | — | — | + 9CT6C§, 10CT6C§ | 7 | — | — | ||||||||||
| + 9CT6C§ | 2 | — | — | + 9CT6C§, 10CT6C§ | 4 | — | — | + 7CT6C§ | 1 | — | — | ||||||||||
| + 7CT6C§ | 1 | — | — | + 16129G>A/G | 1 | — | — | + 10CT6C§, 11CT6C | 1 | — | — | ||||||||||
| + 189A>G/A | 1 | — | — | + 16129G>A | 1 | — | — | + 146T>C | 1 | — | — | ||||||||||
| + 204T>C | 1 | — | — | + 16256C>T/C | 1 | — | — | + 349C>T/C, 368A>G | 1 | — | — | ||||||||||
| + 277C>T | 1 | — | — | Subtotal | 120 | — | — | + 369C>T | 1 | — | — | ||||||||||
| + ins 514CA | 1 | — | — | Subtotal | 51 | — | — | ||||||||||||||
| + 16114C>T | 1 | — | — | ||||||||||||||||||
| Subtotal | 115 | — | — | ||||||||||||||||||
| 2 (38/F) | |||||||||||||||||||||
| Aggregate sequence | 27 | 9 (25.0) | 5 (13.9) | Aggregate sequence | 85 | 9 (9.6) | 3 (3.2) | Aggregate sequence | 24 | 13 (35.1) | 3 (8.1) | ||||||||||
| + 16184C>CC (11C) | 5 | — | — | + 16184C>CC (11C) | 5 | — | — | + 16184C>CC (11C) | 11 | — | — | ||||||||||
| + 16131T>C/T | 1 | — | — | + 16184C>CC | 3 | — | — | + 16184C>CC C | 1 | — | — | ||||||||||
| CC(13)C | (13C) | ||||||||||||||||||||
| + 16145G>A | 1 | — | — | + 478A>G/A | 1 | — | — | + 16459C>T | 1 | — | — | ||||||||||
| + | 1 | — | — | Subtotal | 94 | — | — | Subtotal | 37 | — | — | ||||||||||
| 16184C>CCCC (13C) | |||||||||||||||||||||
| 73A>G, 263A>G, 191A>AA, 194C>T, 199T>C, 207G>A, 8CT6C§, 489T>C, 16147C>T, 16173C>T, 16245C>T, 16362T>C | 1 | — | — | ||||||||||||||||||
| Subtotal | 36 | — | — | ||||||||||||||||||
| 3 (43/M) | |||||||||||||||||||||
| Aggregate sequence | 96 | 24 (20.0) | 7 (5.8) | Aggregate sequence | 66 | 27 (29.0) | 2 (2.2) | Aggregate sequence | 34 | 16 (32.0) | 10 (20.0) | ||||||||||
| + 9CT6C§, 10CT6C§* | 11 | — | — | + 9CT6C§, 10CT6C§ | 26 | — | — | + 9CT6C§, 10CT6C§ | 4 | — | — | ||||||||||
| + 9CT6C§ | 6 | — | — | + 8CT6C§, 9CT6C§, 16124T>C/T | 1 | — | — | + 8CT6C§ | 5 | — | — | ||||||||||
| + 8CT6C§ | 2 | — | — | Subtotal | 93 | — | — | + 8CT6C§, 9CT6C§, 104C>T | 1 | — | — | ||||||||||
| + 182C>T/C, 8CT6C§, 9CT6C§ | 2 | — | — | + 8CT6C§, 9CT6C§, 181A>A/G | 1 | — | — | ||||||||||||||
| + del 71G, 9CT6C§, 10CT6C§ | 1 | — | — | + 8CT6C§, 9CT6C§, 296C>C/T | 1 | — | — | ||||||||||||||
| + 279T>C/T | 1 | — | — | + 8CT6C§, 9CT6C§, 16339C>T | 1 | — | — | ||||||||||||||
| + 16153G>A | 1 | — | — | + 8CT6C§, 9CT6C§, 16352T>T/C | 1 | — | — | ||||||||||||||
| Subtotal | 120 | — | — | + 9CT6C§, 10CT6C§, 225G>A, 16263T>C | 1 | — | — | ||||||||||||||
| + 8CT6C§, 9CT6C§, 16035G>A | 1 | — | — | ||||||||||||||||||
| Subtotal | 50 | — | — | ||||||||||||||||||
| 4 (34/M) | |||||||||||||||||||||
| Aggregate sequence | 92 | 19 (17.1) | 6 (5.4) | Aggregate sequence | 70 | 25 (26.3) | 5 (5.3) | Aggregate sequence | 77 | 34 (30.6) | 16 (14.4) | ||||||||||
| + 8CT6C§, 9CT6C§ | 11 | — | — | + 8CT6C§, 9CT6C§ | 16 | — | — | + 8CT6C§, 9CT6C§ | 6 | — | — | ||||||||||
| + del514-515CA, ins 514CA∥ | 3 | — | — | + 7CT6C§, 8CT6C§ | 3 | — | — | + 7CT6C§, 8CT6C§ | 3 | — | — | ||||||||||
| + 7CT6C§, 8CT6C§ | 2 | — | — | + 16093T>T/C | 4 | — | — | + 9CT6C§, 10CT6C§ | 6 | — | — | ||||||||||
| + 9CT6C§, 10CT6C§ | 1 | — | — | +8CT6C§, 9CT6C§, 16044T>C/T | 1 | — | — | + 9CT6C§, 10CT6C§, 16093T>T/C | 2 | — | — | ||||||||||
| + 89T>C | 1 | — | — | + 8CT6C§, 8CT7C | 1 | — | — | + 16093T>T/C | 3 | — | — | ||||||||||
| + 8CT6C§, 9CT6C§, 16093T∥ | 1 | — | — | Subtotal | 95 | — | — | + 16093T∥ | 4 | — | — | ||||||||||
| Subtotal | 111 | — | — | + 16093T∥, 16208G>A | 1 | — | — | ||||||||||||||
| + 28A>G/A | 1 | — | — | ||||||||||||||||||
| + 8CT6C§, 9CT6C, 185G>G/A | 1 | — | — | ||||||||||||||||||
| + 195T>T/C | 1 | — | — | ||||||||||||||||||
| + 195T>C, 16175A>C | 1 | — | — | ||||||||||||||||||
| + 277C>T | 1 | — | — | ||||||||||||||||||
| + 315C>CT, 315C∥ | 1 | — | — | ||||||||||||||||||
| + 411C>T | 1 | — | — | ||||||||||||||||||
| + del 452T | 1 | — | — | ||||||||||||||||||
| + 469C>T, 16093T>T/C | 1 | — | — | ||||||||||||||||||
| Subtotal | 111 | — | — | ||||||||||||||||||
| 5 (54/M) | |||||||||||||||||||||
| Aggregate sequence | 57 | 57 (50.0) | 14 (12.3) | Aggregate sequence | 64 | 32 (33.3) | 9 (9.4) | Aggregate sequence | 22 | 20 (47.6) | 14 (33.3) | ||||||||||
| + ins 514CA∥ | 19 | — | — | + ins 514CA∥ | 11 | — | — | + 264C>T | 7 | — | — | ||||||||||
| + 264C>T | 18 | — | — | + 264C>T | 10 | — | — | + 146T>C | 1 | — | — | ||||||||||
| + del514-515CA, ins 514CA∥ | 5 | — | — | + 264C>T/C | 3 | — | — | + 7CT6C§, 8CT6C§ | 1 | — | — | ||||||||||
| + 264C>T/C | 3 | — | — | + 146T>C/T, ins 514CA∥ | 4 | — | — | + 8CT6C | 1 | — | — | ||||||||||
| + 7CT6C§, 8CT6C§ | 2 | — | — | + 94G>A/G | 1 | — | — | + 321T>T/C | 1 | — | — | ||||||||||
| + 146T>C, ins 514CA∥ | 2 | — | — | + 16189T>C | 1 | — | — | + 376A>G | 1 | — | — | ||||||||||
| + 146T>C, 264C>T/C | 1 | — | — | + 16265A>G/A | 1 | — | — | + 582T>T/C, 16075T>C/T | 1 | — | — | ||||||||||
| + 146T>C/T, ins | 1 | — | — | + 357A>AA, ins | 1 | — | — | + 1605T>C/T | 1 | — | — | ||||||||||
| 514CA∥ | 514CA∥, | ||||||||||||||||||||
| 16136T>C/T | |||||||||||||||||||||
| + 146T>C | 1 | — | — | Subtotal | 96 | — | — | + 16098A>A/G | 1 | — | — | ||||||||||
| + 189A>G | 1 | — | — | + 16259C>G | 1 | — | — | ||||||||||||||
| + 264C>T/C, ins | 1 | — | — | + 16274G>A, | 1 | — | — | ||||||||||||||
| 514CA∥ | 16296C>T/C | ||||||||||||||||||||
| + 161T>C/T, | 1 | — | — | + 16292C>T | 1 | — | — | ||||||||||||||
| 264C>T, ins | |||||||||||||||||||||
| 514CA∥ | |||||||||||||||||||||
| + 16189T>C | 1 | — | — | + 16322C>T, | 1 | — | — | ||||||||||||||
| 16366C>T | |||||||||||||||||||||
| + 16296C>C/T | 1 | — | — | + 16422T>C | 1 | — | — | ||||||||||||||
| Subtotal | 114 | — | — | Subtotal | 42 | — | — | ||||||||||||||
| 6 (34/F) | |||||||||||||||||||||
| Aggregate sequence | 102 | 13 (11.3) | 6 (5.2) | Aggregate sequence | 69 | 27 (28.1) | 6 (6.3) | Aggregate sequence | 56 | 8 (12.5) | 5 (7.8) | ||||||||||
| + 8CT6C§, | 5 | — | — | + 8CT6C§, | 18 | — | — | + 8CT6C§, | 4 | — | — | ||||||||||
| 9CT6C§ | 9CT6C§ | 9CT6C§ | |||||||||||||||||||
| + 200A>G/A | 3 | — | — | + 200A>G/A | 4 | — | — | + 28A>G | 1 | — | — | ||||||||||
| + 200A>G | 2 | — | — | + 200A>G | 1 | — | — | + 571C>A | 1 | — | — | ||||||||||
| + 200A>G/A, | 1 | — | — | + 200A>G/A, | 2 | — | — | + 16080A>G/A | 1 | — | — | ||||||||||
| 7CT6C§, | 8CT6C§, | ||||||||||||||||||||
| 8CT6C§ | 9CT6C§ | ||||||||||||||||||||
| + 200A>G/A, | 1 | — | — | + 234A>G/A | 1 | — | — | + 16412G>G/A | 1 | — | — | ||||||||||
| 8CT6C§, | |||||||||||||||||||||
| 9CT6C§ | |||||||||||||||||||||
| + 7CT6C§, | 1 | — | — | + 16111C>T/C | 1 | — | — | Subtotal | 64 | — | — | ||||||||||
| 8CT6C§ | |||||||||||||||||||||
| Subtotal | 115 | — | — | Subtotal | 96 | — | — | ||||||||||||||
| Total | 611 | 152 (24.9) | 46 (7.5) | 594 | 150 (25.3) | 30 (5.1) | 355 | 103 (29.0) | 54 (15.2) | ||||||||||||
. | BM CD34 clones‡ . | . | . | . | PB CD34 clones . | . | . | . | Single granulocytes . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor (age, y/sex) . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | mtDNA sequence differences from aggregate sequence* . | . | Heterogeneity . | . | |||||||||
| . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | . | Clone no. . | Frequency, no. (%) . | Unique†no. (%) . | |||||||||
| 1 (47/F) | |||||||||||||||||||||
| Aggregate sequence | 85 | 30 (26.1) | 8 (7.0) | Aggregate sequence | 90 | 30 (25.0) | 5 (4.2) | Aggregate sequence | 39 | 12 (23.1) | 6 (11.5) | ||||||||||
| + 8CT6C§, 9CT6C§ | 22 | — | — | + 8CT6C§, 9CT6C§ | 23 | — | — | + 9CT6C§, 10CT6C§ | 7 | — | — | ||||||||||
| + 9CT6C§ | 2 | — | — | + 9CT6C§, 10CT6C§ | 4 | — | — | + 7CT6C§ | 1 | — | — | ||||||||||
| + 7CT6C§ | 1 | — | — | + 16129G>A/G | 1 | — | — | + 10CT6C§, 11CT6C | 1 | — | — | ||||||||||
| + 189A>G/A | 1 | — | — | + 16129G>A | 1 | — | — | + 146T>C | 1 | — | — | ||||||||||
| + 204T>C | 1 | — | — | + 16256C>T/C | 1 | — | — | + 349C>T/C, 368A>G | 1 | — | — | ||||||||||
| + 277C>T | 1 | — | — | Subtotal | 120 | — | — | + 369C>T | 1 | — | — | ||||||||||
| + ins 514CA | 1 | — | — | Subtotal | 51 | — | — | ||||||||||||||
| + 16114C>T | 1 | — | — | ||||||||||||||||||
| Subtotal | 115 | — | — | ||||||||||||||||||
| 2 (38/F) | |||||||||||||||||||||
| Aggregate sequence | 27 | 9 (25.0) | 5 (13.9) | Aggregate sequence | 85 | 9 (9.6) | 3 (3.2) | Aggregate sequence | 24 | 13 (35.1) | 3 (8.1) | ||||||||||
| + 16184C>CC (11C) | 5 | — | — | + 16184C>CC (11C) | 5 | — | — | + 16184C>CC (11C) | 11 | — | — | ||||||||||
| + 16131T>C/T | 1 | — | — | + 16184C>CC | 3 | — | — | + 16184C>CC C | 1 | — | — | ||||||||||
| CC(13)C | (13C) | ||||||||||||||||||||
| + 16145G>A | 1 | — | — | + 478A>G/A | 1 | — | — | + 16459C>T | 1 | — | — | ||||||||||
| + | 1 | — | — | Subtotal | 94 | — | — | Subtotal | 37 | — | — | ||||||||||
| 16184C>CCCC (13C) | |||||||||||||||||||||
| 73A>G, 263A>G, 191A>AA, 194C>T, 199T>C, 207G>A, 8CT6C§, 489T>C, 16147C>T, 16173C>T, 16245C>T, 16362T>C | 1 | — | — | ||||||||||||||||||
| Subtotal | 36 | — | — | ||||||||||||||||||
| 3 (43/M) | |||||||||||||||||||||
| Aggregate sequence | 96 | 24 (20.0) | 7 (5.8) | Aggregate sequence | 66 | 27 (29.0) | 2 (2.2) | Aggregate sequence | 34 | 16 (32.0) | 10 (20.0) | ||||||||||
| + 9CT6C§, 10CT6C§* | 11 | — | — | + 9CT6C§, 10CT6C§ | 26 | — | — | + 9CT6C§, 10CT6C§ | 4 | — | — | ||||||||||
| + 9CT6C§ | 6 | — | — | + 8CT6C§, 9CT6C§, 16124T>C/T | 1 | — | — | + 8CT6C§ | 5 | — | — | ||||||||||
| + 8CT6C§ | 2 | — | — | Subtotal | 93 | — | — | + 8CT6C§, 9CT6C§, 104C>T | 1 | — | — | ||||||||||
| + 182C>T/C, 8CT6C§, 9CT6C§ | 2 | — | — | + 8CT6C§, 9CT6C§, 181A>A/G | 1 | — | — | ||||||||||||||
| + del 71G, 9CT6C§, 10CT6C§ | 1 | — | — | + 8CT6C§, 9CT6C§, 296C>C/T | 1 | — | — | ||||||||||||||
| + 279T>C/T | 1 | — | — | + 8CT6C§, 9CT6C§, 16339C>T | 1 | — | — | ||||||||||||||
| + 16153G>A | 1 | — | — | + 8CT6C§, 9CT6C§, 16352T>T/C | 1 | — | — | ||||||||||||||
| Subtotal | 120 | — | — | + 9CT6C§, 10CT6C§, 225G>A, 16263T>C | 1 | — | — | ||||||||||||||
| + 8CT6C§, 9CT6C§, 16035G>A | 1 | — | — | ||||||||||||||||||
| Subtotal | 50 | — | — | ||||||||||||||||||
| 4 (34/M) | |||||||||||||||||||||
| Aggregate sequence | 92 | 19 (17.1) | 6 (5.4) | Aggregate sequence | 70 | 25 (26.3) | 5 (5.3) | Aggregate sequence | 77 | 34 (30.6) | 16 (14.4) | ||||||||||
| + 8CT6C§, 9CT6C§ | 11 | — | — | + 8CT6C§, 9CT6C§ | 16 | — | — | + 8CT6C§, 9CT6C§ | 6 | — | — | ||||||||||
| + del514-515CA, ins 514CA∥ | 3 | — | — | + 7CT6C§, 8CT6C§ | 3 | — | — | + 7CT6C§, 8CT6C§ | 3 | — | — | ||||||||||
| + 7CT6C§, 8CT6C§ | 2 | — | — | + 16093T>T/C | 4 | — | — | + 9CT6C§, 10CT6C§ | 6 | — | — | ||||||||||
| + 9CT6C§, 10CT6C§ | 1 | — | — | +8CT6C§, 9CT6C§, 16044T>C/T | 1 | — | — | + 9CT6C§, 10CT6C§, 16093T>T/C | 2 | — | — | ||||||||||
| + 89T>C | 1 | — | — | + 8CT6C§, 8CT7C | 1 | — | — | + 16093T>T/C | 3 | — | — | ||||||||||
| + 8CT6C§, 9CT6C§, 16093T∥ | 1 | — | — | Subtotal | 95 | — | — | + 16093T∥ | 4 | — | — | ||||||||||
| Subtotal | 111 | — | — | + 16093T∥, 16208G>A | 1 | — | — | ||||||||||||||
| + 28A>G/A | 1 | — | — | ||||||||||||||||||
| + 8CT6C§, 9CT6C, 185G>G/A | 1 | — | — | ||||||||||||||||||
| + 195T>T/C | 1 | — | — | ||||||||||||||||||
| + 195T>C, 16175A>C | 1 | — | — | ||||||||||||||||||
| + 277C>T | 1 | — | — | ||||||||||||||||||
| + 315C>CT, 315C∥ | 1 | — | — | ||||||||||||||||||
| + 411C>T | 1 | — | — | ||||||||||||||||||
| + del 452T | 1 | — | — | ||||||||||||||||||
| + 469C>T, 16093T>T/C | 1 | — | — | ||||||||||||||||||
| Subtotal | 111 | — | — | ||||||||||||||||||
| 5 (54/M) | |||||||||||||||||||||
| Aggregate sequence | 57 | 57 (50.0) | 14 (12.3) | Aggregate sequence | 64 | 32 (33.3) | 9 (9.4) | Aggregate sequence | 22 | 20 (47.6) | 14 (33.3) | ||||||||||
| + ins 514CA∥ | 19 | — | — | + ins 514CA∥ | 11 | — | — | + 264C>T | 7 | — | — | ||||||||||
| + 264C>T | 18 | — | — | + 264C>T | 10 | — | — | + 146T>C | 1 | — | — | ||||||||||
| + del514-515CA, ins 514CA∥ | 5 | — | — | + 264C>T/C | 3 | — | — | + 7CT6C§, 8CT6C§ | 1 | — | — | ||||||||||
| + 264C>T/C | 3 | — | — | + 146T>C/T, ins 514CA∥ | 4 | — | — | + 8CT6C | 1 | — | — | ||||||||||
| + 7CT6C§, 8CT6C§ | 2 | — | — | + 94G>A/G | 1 | — | — | + 321T>T/C | 1 | — | — | ||||||||||
| + 146T>C, ins 514CA∥ | 2 | — | — | + 16189T>C | 1 | — | — | + 376A>G | 1 | — | — | ||||||||||
| + 146T>C, 264C>T/C | 1 | — | — | + 16265A>G/A | 1 | — | — | + 582T>T/C, 16075T>C/T | 1 | — | — | ||||||||||
| + 146T>C/T, ins | 1 | — | — | + 357A>AA, ins | 1 | — | — | + 1605T>C/T | 1 | — | — | ||||||||||
| 514CA∥ | 514CA∥, | ||||||||||||||||||||
| 16136T>C/T | |||||||||||||||||||||
| + 146T>C | 1 | — | — | Subtotal | 96 | — | — | + 16098A>A/G | 1 | — | — | ||||||||||
| + 189A>G | 1 | — | — | + 16259C>G | 1 | — | — | ||||||||||||||
| + 264C>T/C, ins | 1 | — | — | + 16274G>A, | 1 | — | — | ||||||||||||||
| 514CA∥ | 16296C>T/C | ||||||||||||||||||||
| + 161T>C/T, | 1 | — | — | + 16292C>T | 1 | — | — | ||||||||||||||
| 264C>T, ins | |||||||||||||||||||||
| 514CA∥ | |||||||||||||||||||||
| + 16189T>C | 1 | — | — | + 16322C>T, | 1 | — | — | ||||||||||||||
| 16366C>T | |||||||||||||||||||||
| + 16296C>C/T | 1 | — | — | + 16422T>C | 1 | — | — | ||||||||||||||
| Subtotal | 114 | — | — | Subtotal | 42 | — | — | ||||||||||||||
| 6 (34/F) | |||||||||||||||||||||
| Aggregate sequence | 102 | 13 (11.3) | 6 (5.2) | Aggregate sequence | 69 | 27 (28.1) | 6 (6.3) | Aggregate sequence | 56 | 8 (12.5) | 5 (7.8) | ||||||||||
| + 8CT6C§, | 5 | — | — | + 8CT6C§, | 18 | — | — | + 8CT6C§, | 4 | — | — | ||||||||||
| 9CT6C§ | 9CT6C§ | 9CT6C§ | |||||||||||||||||||
| + 200A>G/A | 3 | — | — | + 200A>G/A | 4 | — | — | + 28A>G | 1 | — | — | ||||||||||
| + 200A>G | 2 | — | — | + 200A>G | 1 | — | — | + 571C>A | 1 | — | — | ||||||||||
| + 200A>G/A, | 1 | — | — | + 200A>G/A, | 2 | — | — | + 16080A>G/A | 1 | — | — | ||||||||||
| 7CT6C§, | 8CT6C§, | ||||||||||||||||||||
| 8CT6C§ | 9CT6C§ | ||||||||||||||||||||
| + 200A>G/A, | 1 | — | — | + 234A>G/A | 1 | — | — | + 16412G>G/A | 1 | — | — | ||||||||||
| 8CT6C§, | |||||||||||||||||||||
| 9CT6C§ | |||||||||||||||||||||
| + 7CT6C§, | 1 | — | — | + 16111C>T/C | 1 | — | — | Subtotal | 64 | — | — | ||||||||||
| 8CT6C§ | |||||||||||||||||||||
| Subtotal | 115 | — | — | Subtotal | 96 | — | — | ||||||||||||||
| Total | 611 | 152 (24.9) | 46 (7.5) | 594 | 150 (25.3) | 30 (5.1) | 355 | 103 (29.0) | 54 (15.2) | ||||||||||||
Different indicates different from aggregate cell sequence; BM, bone marrow; PB, peripheral blood; and—, not applicable.
The same results are taken from our recent publication.13
The bold sequences indicate identity of sequence alterations in progeny granulocytes and either BM or PB CD34+ progenitors; +, mtDNA nucleotide changes compared with aggregate cell mtDNA sequence.
Unique indicates uniquely different heterogeneity.
Homopolymeric C tract localized between nucleotides 303 and 315 (eg, 8CT6C defined CCCCCCCCTCCCCCC).
Sequence is the same as the Revised Cambridge Reference Sequence but different from the aggregate sequence.