Clonality and clinical characteristics of children with B-lineage ALL
. | Overall (%) . | Patients with 1 sequence (%) . | Patients with more than 1 sequence (%) . | P* . |
|---|---|---|---|---|
| No. | 317 | 256 (81) | 61 (19) | — |
| Median age, y (range) | 4.3 (0.01-17.9) | 4.3 (0.01-17.9) | 4.1 (0.9-16.5) | .56 |
| Sex | .89 | |||
| Male | 167 (53) | 134 (52) | 33 (54) | |
| Female | 150 (47) | 122 (48) | 28 (46) | |
| WBC, × 109/L | .38 | |||
| 0 to less than 20 | 211 (67) | 174 (68) | 37 (60) | |
| 20 to less than 50 | 54 (17) | 40 (16) | 14 (23) | |
| 50 to less than 100 | 28 (9) | 21 (8) | 7 (11) | |
| 100 or more | 23 (7) | 20 (8) | 3 (5) | |
| Relapse | .21 | |||
| No | 275 (87) | 225 (88) | 50 (82) | |
| Yes | 42 (13) | 31 (12) | 11 (18) | |
| Cytogenetic analysis | ||||
| Hyperdiploid more than 50 chromosomes | 53 (17) | 40 (16) | 13 (21) | .34 |
| Hyperdiploid less than 50 chromosomes | 16 (5) | 11 (4) | 5 (8) | .20 |
| Diploid | 83 (26) | 72 (28) | 11 (18) | .14 |
| Pseudo | 35 (11) | 27 (11) | 8 (13) | .65 |
| Hypodiploid | 13 (4) | 11 (4) | 2 (3) | .99 |
| Structure abnormal | 80 (25) | 60 (23) | 20 (33) | .14 |
| 11q23 | 8 (3) | 8 (3) | 0 (0) | .36 |
| t(1;19) | 2 (1) | 2 (1) | 0 (0) | .99 |
| 6q− | 9 (3) | 7 (3) | 2 (3) | .69 |
| 9p− | 7 (2) | 3 (1) | 4 (7) | .03 |
| 12p | 10 (3) | 7 (3) | 3 (5) | .41 |
| Insufficient | 94 (30) | 74 (29) | 20 (33) | .54 |
| ND | 17 (5) | 15 (6) | 2 (3) | .54 |
. | Overall (%) . | Patients with 1 sequence (%) . | Patients with more than 1 sequence (%) . | P* . |
|---|---|---|---|---|
| No. | 317 | 256 (81) | 61 (19) | — |
| Median age, y (range) | 4.3 (0.01-17.9) | 4.3 (0.01-17.9) | 4.1 (0.9-16.5) | .56 |
| Sex | .89 | |||
| Male | 167 (53) | 134 (52) | 33 (54) | |
| Female | 150 (47) | 122 (48) | 28 (46) | |
| WBC, × 109/L | .38 | |||
| 0 to less than 20 | 211 (67) | 174 (68) | 37 (60) | |
| 20 to less than 50 | 54 (17) | 40 (16) | 14 (23) | |
| 50 to less than 100 | 28 (9) | 21 (8) | 7 (11) | |
| 100 or more | 23 (7) | 20 (8) | 3 (5) | |
| Relapse | .21 | |||
| No | 275 (87) | 225 (88) | 50 (82) | |
| Yes | 42 (13) | 31 (12) | 11 (18) | |
| Cytogenetic analysis | ||||
| Hyperdiploid more than 50 chromosomes | 53 (17) | 40 (16) | 13 (21) | .34 |
| Hyperdiploid less than 50 chromosomes | 16 (5) | 11 (4) | 5 (8) | .20 |
| Diploid | 83 (26) | 72 (28) | 11 (18) | .14 |
| Pseudo | 35 (11) | 27 (11) | 8 (13) | .65 |
| Hypodiploid | 13 (4) | 11 (4) | 2 (3) | .99 |
| Structure abnormal | 80 (25) | 60 (23) | 20 (33) | .14 |
| 11q23 | 8 (3) | 8 (3) | 0 (0) | .36 |
| t(1;19) | 2 (1) | 2 (1) | 0 (0) | .99 |
| 6q− | 9 (3) | 7 (3) | 2 (3) | .69 |
| 9p− | 7 (2) | 3 (1) | 4 (7) | .03 |
| 12p | 10 (3) | 7 (3) | 3 (5) | .41 |
| Insufficient | 94 (30) | 74 (29) | 20 (33) | .54 |
| ND | 17 (5) | 15 (6) | 2 (3) | .54 |
WBC indicates white blood cell count; ND, not done.
P value was obtained using the Wilcoxon rank-sum test for age. The Fisher exact test and the χ2 test were used for categoric variables.