Demographic characteristics and causes of death of patients with Chuvash polycythemia and matched cohorts
. | Patients with Chuvash polycythemia, n = 96 . | Spouses, n = 65 . | Community members, n = 94 . | Community members surviving to age 16, n = 76 . |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Median age at time of last contact or death, y (range) | 44 (12-74) | 46 (26-72) | 44 (0.1-81) | 46 (16-81) |
| Female, no. (%) | 55 (57.3) | 28 (43.1) | 53 (56.4) | 43 (56.6) |
| History of smoking, no. (%) | 22 (23.7)* | 22 (36.1)† | 22 (25.0)‡ | 22 (32.4)§ |
| History of alcohol consumption, no. (%) | 21 (22.6)* | 25 (41.0)† | 14 (15.9)‡ | 14 (20.6)§ |
| History of diabetes mellitus, no. (%) | 1 (1.1)* | 2 (3.3)† | 1 (1.1)‡ | 1 (1.5)§ |
| Died during the follow-up period, no. (%) | 45 (46.9) | 11 (16.9) | 28 (29.8) | 11 (14.5) |
| Causes of death, no. | ||||
| Cerebral vascular events∥ | 11 | 1 | 2 | 2 |
| Noncerebral thrombotic events¶ | 10 | 3 | 4 | 4 |
| Trauma | 8 | 3 | 2 | 2 |
| Cardiac valvular disease | 3 | 0 | 0 | 0 |
| Cancer# | 2 | 0 | 1 | 1 |
| Noncerebral hemorrhage | 2 | 0 | 0 | 0 |
| Hypertensive crisis | 1 | 0 | 0 | 0 |
| Pneumonia | 0 | 1 | 9 | 1 |
| Childhood disease (measles; chicken pox) | 0 | 0 | 5 | 0 |
| Other | 8 | 3 | 5 | 1 |
. | Patients with Chuvash polycythemia, n = 96 . | Spouses, n = 65 . | Community members, n = 94 . | Community members surviving to age 16, n = 76 . |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Median age at time of last contact or death, y (range) | 44 (12-74) | 46 (26-72) | 44 (0.1-81) | 46 (16-81) |
| Female, no. (%) | 55 (57.3) | 28 (43.1) | 53 (56.4) | 43 (56.6) |
| History of smoking, no. (%) | 22 (23.7)* | 22 (36.1)† | 22 (25.0)‡ | 22 (32.4)§ |
| History of alcohol consumption, no. (%) | 21 (22.6)* | 25 (41.0)† | 14 (15.9)‡ | 14 (20.6)§ |
| History of diabetes mellitus, no. (%) | 1 (1.1)* | 2 (3.3)† | 1 (1.1)‡ | 1 (1.5)§ |
| Died during the follow-up period, no. (%) | 45 (46.9) | 11 (16.9) | 28 (29.8) | 11 (14.5) |
| Causes of death, no. | ||||
| Cerebral vascular events∥ | 11 | 1 | 2 | 2 |
| Noncerebral thrombotic events¶ | 10 | 3 | 4 | 4 |
| Trauma | 8 | 3 | 2 | 2 |
| Cardiac valvular disease | 3 | 0 | 0 | 0 |
| Cancer# | 2 | 0 | 1 | 1 |
| Noncerebral hemorrhage | 2 | 0 | 0 | 0 |
| Hypertensive crisis | 1 | 0 | 0 | 0 |
| Pneumonia | 0 | 1 | 9 | 1 |
| Childhood disease (measles; chicken pox) | 0 | 0 | 5 | 0 |
| Other | 8 | 3 | 5 | 1 |
Individuals in matched cohorts were traced by personal contact, medical records, civic records, and/or contact with family and community members.
n = 93.
n = 61.
n = 88.
n = 68.
Chuvash polycythemia: 5 hemorrhagic, 5 unspecified, 1 thrombotic. Spouses: 1 hemorrhagic. Community members: 2 unspecified.
Chuvash polycythemia: 4 coronary artery, 4 mesenteric, 1 leg, 1 pulmonary. Spouses: 2 coronary artery, 1 leg. Community members: 4 coronary artery.
Chuvash polycythemia: 1 lung cancer, 1 gastric cancer. Community members: 1 gastric cancer.