Principal transgenic/“knockin” models of BCR/ABL leukemogenesis
Promoter . | BCR/ABL oncogene . | Disease phenotype . | References . |
|---|---|---|---|
| MT | p190 | B-ALL/lymphoma | Voncken et al13,101 ; |
| Heisterkamp et al100 | |||
| MT | p210 b3/a2 | T-ALL; B-ALL; myeloblastic leukemia | Voncken et al101 ; |
| Honda et al102 | |||
| Tec | p210 b3/a2 | T-ALL; CML-like | Honda et al103 |
| MMTV-tTA + tet-p210 | p210 b3/a2 | B-ALL | Huettner et al97 |
| CD34-tTA + tet-p210 | p210 b3/a2 | CML-like; thrombocytosis | Huettner et al104 |
| Endogeneous bcr | p190 | B-ALL | Castellanos et al106 |
Promoter . | BCR/ABL oncogene . | Disease phenotype . | References . |
|---|---|---|---|
| MT | p190 | B-ALL/lymphoma | Voncken et al13,101 ; |
| Heisterkamp et al100 | |||
| MT | p210 b3/a2 | T-ALL; B-ALL; myeloblastic leukemia | Voncken et al101 ; |
| Honda et al102 | |||
| Tec | p210 b3/a2 | T-ALL; CML-like | Honda et al103 |
| MMTV-tTA + tet-p210 | p210 b3/a2 | B-ALL | Huettner et al97 |
| CD34-tTA + tet-p210 | p210 b3/a2 | CML-like; thrombocytosis | Huettner et al104 |
| Endogeneous bcr | p190 | B-ALL | Castellanos et al106 |