Grades 3 and 4 toxicities that occurred in at least 5% of patients
. | All patients, n = 150 . | . | No acute GVHD, n = 79 . | . | Acute GVHD, n = 71 . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | N . | % . | P* . | |||
| Patients who had more than one grade 3 or 4 toxicity | 95 | 63.3 | 42 | 53.2 | 53 | 74.7 | .007 | |||
| Liver | 59 | 39.3 | 26 | 32.9 | 33 | 46.5 | .097 | |||
| Elevated AST | 29 | 19.3 | 12 | 15.2 | 17 | 23.9 | .216 | |||
| Elevated ALT | 40 | 26.7 | 18 | 22.8 | 22 | 31.0 | .273 | |||
| Hyperbilirubinemia | 25 | 16.7 | 7 | 8.9 | 18 | 25.4 | .008 | |||
| Veno-occlusive disease | 18 | 12.0 | 10 | 12.7 | 8 | 11.3 | 1.000 | |||
| Pancreas | 16 | 10.7 | 3 | 3.8 | 13 | 18.3 | .007 | |||
| Hyperglycemia | 15 | 10.0 | 2 | 2.5 | 13 | 18.3 | .002 | |||
| Kidney | 31 | 20.7 | 6 | 7.6 | 25 | 35.2 | < .001 | |||
| Elevated BUN | 7 | 4.7 | 1 | 1.3 | 6 | 8.5 | .053 | |||
| Hematuria | 15 | 10.0 | 2 | 2.5 | 13 | 18.3 | .002 | |||
| Diastolic hypertension | 9 | 7.0 | 4 | 5.1 | 5 | 7.0 | .736 | |||
| Gastrointestinal tract | 47 | 31.3 | 18 | 22.8 | 29 | 40.9 | .022 | |||
| Stomatitis | 39 | 26.0 | 18 | 22.8 | 21 | 29.6 | .358 | |||
| Abdominal pain | 7 | 4.7 | 2 | 2.5 | 5 | 7.0 | .256 | |||
| Diarrhea | 9 | 6.0 | 1 | 1.3 | 8 | 11.3 | .014 | |||
| Nausea and vomiting | 11 | 7.3 | 5 | 6.3 | 6 | 8.5 | .757 | |||
| Skin | 9 | 6.0 | 0 | 0.0 | 9 | 12.7 | .001 | |||
. | All patients, n = 150 . | . | No acute GVHD, n = 79 . | . | Acute GVHD, n = 71 . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | N . | % . | P* . | |||
| Patients who had more than one grade 3 or 4 toxicity | 95 | 63.3 | 42 | 53.2 | 53 | 74.7 | .007 | |||
| Liver | 59 | 39.3 | 26 | 32.9 | 33 | 46.5 | .097 | |||
| Elevated AST | 29 | 19.3 | 12 | 15.2 | 17 | 23.9 | .216 | |||
| Elevated ALT | 40 | 26.7 | 18 | 22.8 | 22 | 31.0 | .273 | |||
| Hyperbilirubinemia | 25 | 16.7 | 7 | 8.9 | 18 | 25.4 | .008 | |||
| Veno-occlusive disease | 18 | 12.0 | 10 | 12.7 | 8 | 11.3 | 1.000 | |||
| Pancreas | 16 | 10.7 | 3 | 3.8 | 13 | 18.3 | .007 | |||
| Hyperglycemia | 15 | 10.0 | 2 | 2.5 | 13 | 18.3 | .002 | |||
| Kidney | 31 | 20.7 | 6 | 7.6 | 25 | 35.2 | < .001 | |||
| Elevated BUN | 7 | 4.7 | 1 | 1.3 | 6 | 8.5 | .053 | |||
| Hematuria | 15 | 10.0 | 2 | 2.5 | 13 | 18.3 | .002 | |||
| Diastolic hypertension | 9 | 7.0 | 4 | 5.1 | 5 | 7.0 | .736 | |||
| Gastrointestinal tract | 47 | 31.3 | 18 | 22.8 | 29 | 40.9 | .022 | |||
| Stomatitis | 39 | 26.0 | 18 | 22.8 | 21 | 29.6 | .358 | |||
| Abdominal pain | 7 | 4.7 | 2 | 2.5 | 5 | 7.0 | .256 | |||
| Diarrhea | 9 | 6.0 | 1 | 1.3 | 8 | 11.3 | .014 | |||
| Nausea and vomiting | 11 | 7.3 | 5 | 6.3 | 6 | 8.5 | .757 | |||
| Skin | 9 | 6.0 | 0 | 0.0 | 9 | 12.7 | .001 | |||
AST indicates aspartate aminotransferase; ALT, alanine aminotransferase; and BUN, blood urea nitrogen.
P values for comparison of toxicity incidence for patients with and without acute GVHD.