Association of thrombophilia with placental vascular complications
. | Miscarriages . | IUFD . | Severe IUGR . | Severe preeclampsia . | Placental abruption . |
|---|---|---|---|---|---|
| Antithrombin deficiency | I+ (11,12) | I+ (11,12) | II+ | II+ | III+ |
| Protein C deficiency | I+ (11,12) | I+ (11,12) | ND | ND | III+ |
| Protein S deficiency | I (11-13) | I+ (11,12) | II+ (14) | II+ (14) | III+ (14) |
| Dysfibrinogenemia | II+ (15) | II+ (15) | ND | ND | ND |
| APC resistance | I+ (13,16) | I+ (13,16) | II+ | II+ | II+ (18) |
| Factor V Leiden | I+ (13,19-23) | I+ (13,19-23) | II+ (24-26) | II+ (26-31) | II+ (18,26,32) |
| MTHFR 677TT | I- (33) | I- (14) | II- (14,34,35) | II- (14,28-30,34,35) | II- |
| Hyperhomocysteinemia | I+ (33,35) | I+ (14,35) | II+ (14,35) | II+ | II+ (14,34,36) |
| Factor II 20210G>A | I+ (17,23) | I+ (17,23) | II+ (24-26) | II+ (25,29-31) | II+ (26,32) |
| Antiphospholipid antibodies | I+ (13,37) | I+ (13,37) | II+ (26) | II+ (26) | II+ (26) |
| Combined defects | I+ (12,13,37) | I+ (12,13,26,37) | II+ (26) | II+ (26) | II+ (26) |
. | Miscarriages . | IUFD . | Severe IUGR . | Severe preeclampsia . | Placental abruption . |
|---|---|---|---|---|---|
| Antithrombin deficiency | I+ (11,12) | I+ (11,12) | II+ | II+ | III+ |
| Protein C deficiency | I+ (11,12) | I+ (11,12) | ND | ND | III+ |
| Protein S deficiency | I (11-13) | I+ (11,12) | II+ (14) | II+ (14) | III+ (14) |
| Dysfibrinogenemia | II+ (15) | II+ (15) | ND | ND | ND |
| APC resistance | I+ (13,16) | I+ (13,16) | II+ | II+ | II+ (18) |
| Factor V Leiden | I+ (13,19-23) | I+ (13,19-23) | II+ (24-26) | II+ (26-31) | II+ (18,26,32) |
| MTHFR 677TT | I- (33) | I- (14) | II- (14,34,35) | II- (14,28-30,34,35) | II- |
| Hyperhomocysteinemia | I+ (33,35) | I+ (14,35) | II+ (14,35) | II+ | II+ (14,34,36) |
| Factor II 20210G>A | I+ (17,23) | I+ (17,23) | II+ (24-26) | II+ (25,29-31) | II+ (26,32) |
| Antiphospholipid antibodies | I+ (13,37) | I+ (13,37) | II+ (26) | II+ (26) | II+ (26) |
| Combined defects | I+ (12,13,37) | I+ (12,13,26,37) | II+ (26) | II+ (26) | II+ (26) |
Reference numbers are listed in parentheses.
Level I (I) indicates the recommendation is based on 1 or more well-designed prospective studies or 2 or more well-designed retrospective studies; level II (II), the recommendation is based on retrospective studies that reach consensus; level III (III), the recommendation is based on isolated anecdotal studies and/or the consensus of expert practitioners; +, association present; -, association not present; and ND, no data.