Details of patients who received treatment
Patient . | Donor . | T cell depletion . | Symptoms . | EBV DNA . | Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| J31 | 6 of 6 URD | Ex vivo T-cell depletion | Fever, pneumonia | 40 000 | CTLs | Symptoms resolved, and EBV DNA returned to normal |
| J23 | 6 of 6 URD | Ex vivo T-cell depletion | Fever | 4 000 | CTLs and rituximab | Symptoms resolved, and EBV DNA returned to normal |
| 2110 | 6 of 6 URD | Ex vivo T-cell depletion | Lymphadenopathy | 20 000 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J28 | 6 of 6 URD | Ex vivo T-cell depletion | Cough, fever | 36 539 | CTLs | Symptoms resolved, EBV DNA decreased but remained above normal for several months |
| J180 | 6 of 6 URD | Ex vivo T- and B-cell depletion | Abdominal pain, after ATG for GVHD | 176 009 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J152 | 4 of 6 mother | Ex vivo T- and B-cell depletion | Fever | 29 807 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J383 | 6 of 6 URD | In vivo alemtuzumab | Fever | 74 346 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J366 | 5 of 6 mother | In vivo alemtuzumab | Fever | 103 695 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
Patient . | Donor . | T cell depletion . | Symptoms . | EBV DNA . | Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| J31 | 6 of 6 URD | Ex vivo T-cell depletion | Fever, pneumonia | 40 000 | CTLs | Symptoms resolved, and EBV DNA returned to normal |
| J23 | 6 of 6 URD | Ex vivo T-cell depletion | Fever | 4 000 | CTLs and rituximab | Symptoms resolved, and EBV DNA returned to normal |
| 2110 | 6 of 6 URD | Ex vivo T-cell depletion | Lymphadenopathy | 20 000 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J28 | 6 of 6 URD | Ex vivo T-cell depletion | Cough, fever | 36 539 | CTLs | Symptoms resolved, EBV DNA decreased but remained above normal for several months |
| J180 | 6 of 6 URD | Ex vivo T- and B-cell depletion | Abdominal pain, after ATG for GVHD | 176 009 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J152 | 4 of 6 mother | Ex vivo T- and B-cell depletion | Fever | 29 807 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J383 | 6 of 6 URD | In vivo alemtuzumab | Fever | 74 346 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
| J366 | 5 of 6 mother | In vivo alemtuzumab | Fever | 103 695 | Rituximab | Symptoms resolved, and EBV DNA returned to normal |
URD indicates unrelated donor.