Demographics of 85 patients
. | No. patients (%) . |
|---|---|
| Sex | |
| Male | 48 (56) |
| Female | 37 (44) |
| Diagnosis | |
| Acute lymphocytic leukemia | 30 (35.3) |
| Acute myelocytic leukemia | 16 (18.8) |
| Non-Hodgkin leukemia | 5 (5.9) |
| Chronic myelocytic leukemia | 2 (2.4) |
| Hodgkin disease | 1 (1.2) |
| Aplastic anemia | 13 (15.3) |
| Myelodysplastic syndrome | 7 (8.2) |
| Severe combined immunodeficiency | 1 (1.2) |
| Wiskott-Aldrich syndrome | 1 (1.2) |
| Virus-associated hemophagocytic syndrome | 6 (7.6) |
| Metabolic disease (Hurler disease) | 3 (3.5) |
| Transplantation regimen | |
| Full conditioning including ATG, no T or B cell depletion | 25 (24.5) |
| Full conditioning including ATG, T cell depletion | 8 (9.9) |
| Full conditioning including ATG, T and B cell depletion | 31 (42.0) |
| Full conditioning including alemtuzumab, no T or B cell depletion | 21 (23.5) |
| Graft type | |
| Unrelated donor | |
| Matched (6 of 6) | 44 (51.8) |
| Mismatched (5 of 6) | 26 (30.6) |
| Related donor | |
| Matched (6 of 6) | 1 (1.2) |
| Mismatched (5 of 6, 4 of 6) | 9 (10.6) |
| Haploidentical (3 of 6) | 5 (5.9) |
. | No. patients (%) . |
|---|---|
| Sex | |
| Male | 48 (56) |
| Female | 37 (44) |
| Diagnosis | |
| Acute lymphocytic leukemia | 30 (35.3) |
| Acute myelocytic leukemia | 16 (18.8) |
| Non-Hodgkin leukemia | 5 (5.9) |
| Chronic myelocytic leukemia | 2 (2.4) |
| Hodgkin disease | 1 (1.2) |
| Aplastic anemia | 13 (15.3) |
| Myelodysplastic syndrome | 7 (8.2) |
| Severe combined immunodeficiency | 1 (1.2) |
| Wiskott-Aldrich syndrome | 1 (1.2) |
| Virus-associated hemophagocytic syndrome | 6 (7.6) |
| Metabolic disease (Hurler disease) | 3 (3.5) |
| Transplantation regimen | |
| Full conditioning including ATG, no T or B cell depletion | 25 (24.5) |
| Full conditioning including ATG, T cell depletion | 8 (9.9) |
| Full conditioning including ATG, T and B cell depletion | 31 (42.0) |
| Full conditioning including alemtuzumab, no T or B cell depletion | 21 (23.5) |
| Graft type | |
| Unrelated donor | |
| Matched (6 of 6) | 44 (51.8) |
| Mismatched (5 of 6) | 26 (30.6) |
| Related donor | |
| Matched (6 of 6) | 1 (1.2) |
| Mismatched (5 of 6, 4 of 6) | 9 (10.6) |
| Haploidentical (3 of 6) | 5 (5.9) |
Median patient age was 7 years (range, 3 months to 36 years). Full-conditioning regimens included cyclophosphamide, Ara C, and total body irradiation (TBI),12 busulphan, cyclophosphamide, and Ara C, or cyclophospahmide and TBI.13 ATG indicates antithymocyte globulin.