Table 1. Effects of Bay 11-7082 ± UCN-01... | American Society of Hematology

Table 1.

Effects of Bay 11-7082 ± UCN-01 on the cell-cycle traverse of U266 cells

	Control	Bay 11-7082	UCN-01	Bay + UCN
G₀/G₁	46.78 ± 0.78	62.39 ± 1.06^*	57.30 ± 1.18^*	60.17 ± 0.78^*
S	42.55 ± 1.45	26.04 ± 1.53^*	35.61 ± 1.68†	30.64 ± 1.98^*
G₂/M	10.67 ± 0.87	11.6 ± 0.51	7.12 ± 0.56†	9.19 ± 1.45

	Control	Bay 11-7082	UCN-01	Bay + UCN
G₀/G₁	46.78 ± 0.78	62.39 ± 1.06^*	57.30 ± 1.18^*	60.17 ± 0.78^*
S	42.55 ± 1.45	26.04 ± 1.53^*	35.61 ± 1.68†	30.64 ± 1.98^*
G₂/M	10.67 ± 0.87	11.6 ± 0.51	7.12 ± 0.56†	9.19 ± 1.45

U226 cells were exposed to 4 μM Bay 11-7082 ± 200 nM UCN-01 for 24 hours, after which PI staining and flow cytometric analysis were performed to monitor effects on each phase of the cell cycle, as described in “Materials and methods.” Values are expressed as the percentage of cells in the indicated phase of the cell cycle relative to the total nonapoptotic cell population and represent the means ± SDs for 3 separate experiments performed in triplicate.

^*P < .001 and †P < .01 significantly higher (G₀/G₁) or lower (S and G₂/M) than values for untreated control cells.

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