DC content and DC1/DC2 ratio in PB and BM of patients after allogeneic SCT
. | PB DCs . | . | . | BM DCs . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | DC1 + DC2, % TNCs . | DC1 + DC2, × 10-3/mL . | DC1/DC2 ratio . | DC1 + DC2, % TNCs . | DC1 + DC2, × 10-3/mL . | DC1/DC2 ratio . | ||||
| Donors (n = 13/6) | 0.41 ± 0.04 | 23.6 ± 2.2 | 2.4 ± 0.5 | 0.79 ± 0.10 | 129.0 ± 1.94 | 2.5 ± 0.3 | ||||
| Patients after SCT | ||||||||||
| Day 7 (n = 24/0) | 0.14 ± 0.04* | 1.1 ± 0.7† | NA | ND | ND | ND | ||||
| Day 14 (n = 24/9) | 0.76 ± 0.23 | 14.6 ± 3.3* | 8.7 ± 2.9† | 0.61 ± 0.22 | 38.4 ± 14.8† | 12.0 ± 1.1† | ||||
| Day 30 (n = 20/17) | 0.45 ± 0.11 | 20.3 ± 3.7 | 5.1 ± 0.7* | 1.03 ± 0.16 | 147.0 ± 52.6 | 15.4 ± 4.5† | ||||
| Day 90 (n = 15/12) | 0.42 ± 0.17 | 11.3 ± 2.3* | 10.6 ± 4.3* | 0.55 ± 0.10* | 51.6 ± 9.5* | 17.3 ± 3.5† | ||||
| Day 180 (n = 10/10) | 0.43 ± 0.11 | 18.9 ± 6.0 | 3.8 ± 1.5 | 0.84 ± 0.15 | 80.6 ± 17.6 | 13.0 ± 2.1† | ||||
. | PB DCs . | . | . | BM DCs . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | DC1 + DC2, % TNCs . | DC1 + DC2, × 10-3/mL . | DC1/DC2 ratio . | DC1 + DC2, % TNCs . | DC1 + DC2, × 10-3/mL . | DC1/DC2 ratio . | ||||
| Donors (n = 13/6) | 0.41 ± 0.04 | 23.6 ± 2.2 | 2.4 ± 0.5 | 0.79 ± 0.10 | 129.0 ± 1.94 | 2.5 ± 0.3 | ||||
| Patients after SCT | ||||||||||
| Day 7 (n = 24/0) | 0.14 ± 0.04* | 1.1 ± 0.7† | NA | ND | ND | ND | ||||
| Day 14 (n = 24/9) | 0.76 ± 0.23 | 14.6 ± 3.3* | 8.7 ± 2.9† | 0.61 ± 0.22 | 38.4 ± 14.8† | 12.0 ± 1.1† | ||||
| Day 30 (n = 20/17) | 0.45 ± 0.11 | 20.3 ± 3.7 | 5.1 ± 0.7* | 1.03 ± 0.16 | 147.0 ± 52.6 | 15.4 ± 4.5† | ||||
| Day 90 (n = 15/12) | 0.42 ± 0.17 | 11.3 ± 2.3* | 10.6 ± 4.3* | 0.55 ± 0.10* | 51.6 ± 9.5* | 17.3 ± 3.5† | ||||
| Day 180 (n = 10/10) | 0.43 ± 0.11 | 18.9 ± 6.0 | 3.8 ± 1.5 | 0.84 ± 0.15 | 80.6 ± 17.6 | 13.0 ± 2.1† | ||||
All numbers are expressed as mean ± SEM. % TNCs indicates percent of total nucleated cells, and DC1/DC2 ratio is the mean of ratios calculated for each patient. n indicates number of PB/BM samples analyzed at each time point; NA, not applicable due to low cell numbers; and ND, not done.
P < .05 compared with healthy controls.
P < .005 compared with healthy controls.