Ploidy levels in Aurora-BAIM-1 transgenic mice
. | > 4N . | 2N . | 4N . | 8N . | 16N . | 32N . | 64N . | 128 . | > 128N . |
|---|---|---|---|---|---|---|---|---|---|
| Wild-type (n = 8) | 61.3 ± 3.2 | 26.0 ± 2.0 | 12.8 ± 2.0 | 9.4 ± 4.0 | 37.0 ± 2.4 | 11.0 ± 2.0 | 1.6 ± 0.9 | 1.2 ± 0.9 | 0 |
| TG74 (n = 4) | 64.8 ± 4.7 | 22.4 ± 3.3 | 12.9 ± 1.5 | 9.1 ± 1.8 | 40.6 ± 3.0 | 12.4 ± 1.9 | 1.6 ± 0.5 | 0.9 ± 0.3 | 0 |
| TG58 (n = 8) | 55.2 ± 13.2 | 27.1 ± 6.4 | 17.7 ± 7.6 | 10.4 ± 5.8 | 30.8 ± 15.1 | 10.2 ± 3.7 | 2.5 ± 2.1 | 1.3 ± 0.9 | 0 |
| TG58-29 | 33.9 | 40.6 | 25.5 | 5.3 | 5.3 | 12.8 | 7.3 | 2.9 | 0.2 |
| TG58-31 | 36.9 | 31.2 | 31.9 | 24.1 | 9.8 | 1.6 | 1.2 | 0.2 | 0 |
. | > 4N . | 2N . | 4N . | 8N . | 16N . | 32N . | 64N . | 128 . | > 128N . |
|---|---|---|---|---|---|---|---|---|---|
| Wild-type (n = 8) | 61.3 ± 3.2 | 26.0 ± 2.0 | 12.8 ± 2.0 | 9.4 ± 4.0 | 37.0 ± 2.4 | 11.0 ± 2.0 | 1.6 ± 0.9 | 1.2 ± 0.9 | 0 |
| TG74 (n = 4) | 64.8 ± 4.7 | 22.4 ± 3.3 | 12.9 ± 1.5 | 9.1 ± 1.8 | 40.6 ± 3.0 | 12.4 ± 1.9 | 1.6 ± 0.5 | 0.9 ± 0.3 | 0 |
| TG58 (n = 8) | 55.2 ± 13.2 | 27.1 ± 6.4 | 17.7 ± 7.6 | 10.4 ± 5.8 | 30.8 ± 15.1 | 10.2 ± 3.7 | 2.5 ± 2.1 | 1.3 ± 0.9 | 0 |
| TG58-29 | 33.9 | 40.6 | 25.5 | 5.3 | 5.3 | 12.8 | 7.3 | 2.9 | 0.2 |
| TG58-31 | 36.9 | 31.2 | 31.9 | 24.1 | 9.8 | 1.6 | 1.2 | 0.2 | 0 |
All values are percentages.
Ploidy profiles of bone marrow cells from transgenic mice were analyzed and compared with those of wild-type mice. Average percentages of cells (± SD) that contained DNA content greater that 4N reflect the average ploidy level in each line. Some of the transgenic mice from line TG58 (TG58-29 and TG58-31, singled out in the table) displayed sharp decreases in ploidy level.