Potential risk factors for low bone mass and rapid bone loss
. | Statistical analysis/grouping . |
|---|---|
| Risk factors present at transplantation | |
| Type of underlying disease | AML, ALL, CML, MDS, other |
| Time from diagnosis to transplantation | Continuous variable |
| Pretransplantation treatment | High-toxicity chemotherapy/low-toxicity chemotherapy |
| Age at transplantation | Continuous variable |
| Sex (male/female) (recipient and donor) | |
| Body indices at baseline | Weight, fat mass, percent fat mass, muscle mass, percent muscle mass, BMI |
| Transplantation-associated risk factors | |
| Pre-existing osteoporosis | Z-scores of all sites of measurement |
| Continuous variable | |
| Conditioning therapy | Conditioning: TBI + Cy, CyBuThio, other |
| Total body irradiation applied: yes/no | |
| HLA match | Related donor match, related donor mismatch, unrelated donor match, unrelated donor mismatch |
| Length of stay in transplantation unit | Continuous variable |
| Development of acute GVHD | 0 (grade 0 or 1), 1 (grades 2 to 4) |
| Development of chronic GVHD | Yes/no |
| Steroid medication | Cumulative steroid in gram total, in milligram per kilogram BW, in milligram per day; in percent of days under steroid medication |
| Cyclosporine A medication | In percent of days under cyclosporine A medication |
| Changes of body indices | Changes of: weight, fat mass, percent fat mass, muscle mass, percent muscle mass, BMI |
. | Statistical analysis/grouping . |
|---|---|
| Risk factors present at transplantation | |
| Type of underlying disease | AML, ALL, CML, MDS, other |
| Time from diagnosis to transplantation | Continuous variable |
| Pretransplantation treatment | High-toxicity chemotherapy/low-toxicity chemotherapy |
| Age at transplantation | Continuous variable |
| Sex (male/female) (recipient and donor) | |
| Body indices at baseline | Weight, fat mass, percent fat mass, muscle mass, percent muscle mass, BMI |
| Transplantation-associated risk factors | |
| Pre-existing osteoporosis | Z-scores of all sites of measurement |
| Continuous variable | |
| Conditioning therapy | Conditioning: TBI + Cy, CyBuThio, other |
| Total body irradiation applied: yes/no | |
| HLA match | Related donor match, related donor mismatch, unrelated donor match, unrelated donor mismatch |
| Length of stay in transplantation unit | Continuous variable |
| Development of acute GVHD | 0 (grade 0 or 1), 1 (grades 2 to 4) |
| Development of chronic GVHD | Yes/no |
| Steroid medication | Cumulative steroid in gram total, in milligram per kilogram BW, in milligram per day; in percent of days under steroid medication |
| Cyclosporine A medication | In percent of days under cyclosporine A medication |
| Changes of body indices | Changes of: weight, fat mass, percent fat mass, muscle mass, percent muscle mass, BMI |
MDS indicates myelodysplasia; other, severe aplastic anemia, Hodgkin disease, myelosarcoma, multiple myeloma, or non-Hodgkin lymphoma.