Table 1. Tissue iron concentration in... | American Society of Hematology

Table 1.

Tissue iron concentration in mice fed a standard or iron-enriched diet (2.5% wt/wt carbonyl iron) for 3 months

	μg iron/g dry wt
Organ	B6	*Rag1*^−/−	*Hfe*^−/−	*HfeRag1*^−/−	β2m^−/−	β2mRag1^−/−
Standard diet
	n = 14	n = 9	n = 14	n = 12	n = 9	n = 11
Liver	287 ± 63	298 ± 43	1034 ± 253^*	1607 ± 730†‡	788 ± 279^*	840 ± 292^*
Heart	358 ± 52	371 ± 59	409 ± 45	412 ± 90	439 ± 57	586 ± 134§
Pancreas	160 ± 35	151 ± 30	173 ± 45	185 ± 42	178 ± 38	676 ± 276∥
Iron-enriched diet
	n = 10	n = 10	n = 10	n = 10	n = 9	n = 11
Liver	4014 ± 1186	4279 ± 549	7276 ± 1247^*	12077 ± 4584‡¶	5742 ± 985^*¶	6118 ± 1462^*
Heart	467 ± 70	508 ± 72	500 ± 117	485 ± 84	501 ± 72	1181 ± 265∥
Pancreas	252 ± 72	287 ± 83	253 ± 23	279 ± 106	283 ± 46	3844 ± 2010§

	μg iron/g dry wt
Organ	B6	*Rag1*^−/−	*Hfe*^−/−	*HfeRag1*^−/−	β2m^−/−	β2mRag1^−/−
Standard diet
	n = 14	n = 9	n = 14	n = 12	n = 9	n = 11
Liver	287 ± 63	298 ± 43	1034 ± 253^*	1607 ± 730†‡	788 ± 279^*	840 ± 292^*
Heart	358 ± 52	371 ± 59	409 ± 45	412 ± 90	439 ± 57	586 ± 134§
Pancreas	160 ± 35	151 ± 30	173 ± 45	185 ± 42	178 ± 38	676 ± 276∥
Iron-enriched diet
	n = 10	n = 10	n = 10	n = 10	n = 9	n = 11
Liver	4014 ± 1186	4279 ± 549	7276 ± 1247^*	12077 ± 4584‡¶	5742 ± 985^*¶	6118 ± 1462^*
Heart	467 ± 70	508 ± 72	500 ± 117	485 ± 84	501 ± 72	1181 ± 265∥
Pancreas	252 ± 72	287 ± 83	253 ± 23	279 ± 106	283 ± 46	3844 ± 2010§

Mice (females) were 5 months old at the end of the experiment. Data are presented as mean ± SD.

P < .005 compared with B6 or Rag1^−/− mice by Student t test.

P < .01 compared with Hfe^−/− mice by Student t test.

P < .001 compared with β2mRag1^−/− mice by Student t test.

P < .01 by Student t test compared with all other mouse strains.

P < .0001 by Student t test compared with all other mouse strains.

P < .05 compared with Hfe^−/− mice by Student t test.