Table 2. Pharmacokinetic studies: plasma... | American Society of Hematology

Table 2.

Pharmacokinetic studies: plasma concentration CEP-701 ng/mL

Time point	40 mg twice daily*	60 mg twice daily†
Baseline, time 0	BLQ	BLQ
Day 1, 1 hour after, ng/mL
Mean	782	1604.62
Median	650.9	1741.6
Range	510.0-1184.7	166.5-2649.8
Day 2, 1 hour before, ng/mL
Mean	798.6	1410.32
Median	386.4	918.1
Range	159.1-1850.3	192.4-4242.8
Day 28, 1 hour before, ng/mL
Mean	2982.5‡	1925.9§
Median	2982.5‡	1388.85§
Range	NA‡	498.2-5850.7§
Day 28, 1 hour after, ng/mL
Mean	NA	3401.6§
Median	NA	2899.2§
Range	NA	924.4-7625.2§

Time point	40 mg twice daily*	60 mg twice daily†
Baseline, time 0	BLQ	BLQ
Day 1, 1 hour after, ng/mL
Mean	782	1604.62
Median	650.9	1741.6
Range	510.0-1184.7	166.5-2649.8
Day 2, 1 hour before, ng/mL
Mean	798.6	1410.32
Median	386.4	918.1
Range	159.1-1850.3	192.4-4242.8
Day 28, 1 hour before, ng/mL
Mean	2982.5‡	1925.9§
Median	2982.5‡	1388.85§
Range	NA‡	498.2-5850.7§
Day 28, 1 hour after, ng/mL
Mean	NA	3401.6§
Median	NA	2899.2§
Range	NA	924.4-7625.2§

BLQ indicates below the limit of quantitation; NA, value not available.

n = 3.

n = 13.

Result from 1 patient.

Results from 8 patients.