Commercially available cGK and cAK activators/inhibitors used in the study
Material . | Function . | Purity, % . | Source* . |
|---|---|---|---|
| Glyco-SNAP | Stable NO donor | > 96 | Calbiochem |
| SNAP | NO donor | 95 | Calbiochem |
| 8-Br-cAMP | Cell-permeable cAK activator | > 99 | Biolog |
| Rp-8-Br-cAMPS | Cell-permeable cAK inhibitor | > 99 | Biolog |
| Myristoylated PKI | Cell-permeable cAK inhibitor | > 97 | Calbiochem |
| H89 | cAK inhibitor | 99 | Calbiochem |
| cGMP | cGK activator | > 99 | Biolog |
| GMP | Hydrolysis product of cGMP | > 99 | Sigma |
| 8-pCPT-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-Pet-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-GMP | Hydrolysis product of 8-Br-cGMP | 95-98 | Sigma |
| Rp-8-pCPT-cGMPS | Cell-permeable cGK inhibitor | > 99 | Biolog |
| Rp-8-Br-Pet-cGMPS | Cell-permeable cGK inhibitor | > 99 | Biolog |
Material . | Function . | Purity, % . | Source* . |
|---|---|---|---|
| Glyco-SNAP | Stable NO donor | > 96 | Calbiochem |
| SNAP | NO donor | 95 | Calbiochem |
| 8-Br-cAMP | Cell-permeable cAK activator | > 99 | Biolog |
| Rp-8-Br-cAMPS | Cell-permeable cAK inhibitor | > 99 | Biolog |
| Myristoylated PKI | Cell-permeable cAK inhibitor | > 97 | Calbiochem |
| H89 | cAK inhibitor | 99 | Calbiochem |
| cGMP | cGK activator | > 99 | Biolog |
| GMP | Hydrolysis product of cGMP | > 99 | Sigma |
| 8-pCPT-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-Pet-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-cGMP | Cell-permeable cGK activator | > 99 | Biolog |
| 8-Br-GMP | Hydrolysis product of 8-Br-cGMP | 95-98 | Sigma |
| Rp-8-pCPT-cGMPS | Cell-permeable cGK inhibitor | > 99 | Biolog |
| Rp-8-Br-Pet-cGMPS | Cell-permeable cGK inhibitor | > 99 | Biolog |
Locations for the sources are as follows: Calbiochem, San Diego, CA; Biolog, Hayward, CA; and Sigma, St Louis, MO