Table 1. Immunologic characterization of... | American Society of Hematology

Table 1.

Immunologic characterization of ICF patients

					HD
	P1	P2	P3	P4	HD1	HD2
Age, years	3	16	9	4	2-5	10-16
Serum lg levels, g/L^*
IgM	< 0.06	0.2	0.06	< 0.06	0.56 ± 0.18	0.6 ± 0.26
IgG	0.6	4.4	0.06	0.31	9.29 ± 2.28	10.34 ± 1.79
IgA	< 0.05	0.07	0.06	0.05	0.93 ± 0.27	1.39 ± 0.71
Lymphocytes, %†
CD3⁺	52	83	83	81	64 (43-76)	67 (52-78)
CD3⁺CD4⁺	33	13	55	62	37 (23-48)	39 (25-48)
CD3⁺CD8⁺	18	72	21	17	24 (14-33)	23 (9-35)
CD3⁻CD56⁺	5.6	ND	5	ND	10 (4-23)	15 (6-27)
CD19⁺	20	5	7	14	24 (14-44)	16 (8-24)
Lymphocytes, no. × 10⁹/L†
CD3⁺	4.12	1.99	2.12	3.11	2.3 (0.9-4.5)	1.5 (0.8-3.5)
CD3⁻CD56⁺	0.34	ND	0.1	ND	0.4 (0.1-1)	0.3 (0.07-1.2)
CD19⁺	1.2	0.47	0.25	1.03	0.8 (0.2-2.1)	0.3 (0.2-0.6)
Proliferation
PHA	+	+	+	+	ND	ND
PWM	+	+	ND	+	ND	ND
ConA	ND	+	ND	ND	ND	ND
Tetanus toxoid	+	−	+	−	ND	ND
Candidin	−	−	+	−	ND	ND

					HD
	P1	P2	P3	P4	HD1	HD2
Age, years	3	16	9	4	2-5	10-16
Serum lg levels, g/L^*
IgM	< 0.06	0.2	0.06	< 0.06	0.56 ± 0.18	0.6 ± 0.26
IgG	0.6	4.4	0.06	0.31	9.29 ± 2.28	10.34 ± 1.79
IgA	< 0.05	0.07	0.06	0.05	0.93 ± 0.27	1.39 ± 0.71
Lymphocytes, %†
CD3⁺	52	83	83	81	64 (43-76)	67 (52-78)
CD3⁺CD4⁺	33	13	55	62	37 (23-48)	39 (25-48)
CD3⁺CD8⁺	18	72	21	17	24 (14-33)	23 (9-35)
CD3⁻CD56⁺	5.6	ND	5	ND	10 (4-23)	15 (6-27)
CD19⁺	20	5	7	14	24 (14-44)	16 (8-24)
Lymphocytes, no. × 10⁹/L†
CD3⁺	4.12	1.99	2.12	3.11	2.3 (0.9-4.5)	1.5 (0.8-3.5)
CD3⁻CD56⁺	0.34	ND	0.1	ND	0.4 (0.1-1)	0.3 (0.07-1.2)
CD19⁺	1.2	0.47	0.25	1.03	0.8 (0.2-2.1)	0.3 (0.2-0.6)
Proliferation
PHA	+	+	+	+	ND	ND
PWM	+	+	ND	+	ND	ND
ConA	ND	+	ND	ND	ND	ND
Tetanus toxoid	+	−	+	−	ND	ND
Candidin	−	−	+	−	ND	ND

HD indicates healthy donor; ND, not determined; PHA, phytohemagglutinin; PWM, pokeweed mitogen; ConA, concavalin A.

Levels of immunoglobulins in sera of HDs are from Stiehm and Fudenberg.³⁰

Data on lymphocyte populations in peripheral blood of HD are from Comans-Bitter et al.³¹