Cosegregation of splenomegaly with chromosome 8 markers in different informative F2 crosses
Markers . | Distance from telomere, cM* . | B6/B6,†high-low . | B6/A + A/A,†high-low . | χ2 . | LOD . |
|---|---|---|---|---|---|
| (BALB/c × BXH-2)F2, n = 118 | |||||
| D8Mit86 | 54.6 | 27:10 | 6:75 | 60.8 | 13.2 |
| D8Mit200 | 60.1 | 31:5 | 2:80 | 128.3 | 27.9 |
| D8Mit13‡ | 68.9 | 31:2 | 2:83 | 158.8 | 34.5‡ |
| D8Mit326 | 74.3 | 28:3 | 5:82 | 114.7 | 24.9 |
| (A/J × BXH-2)F2, n = 91 | |||||
| D8Mit86 | 54.6 | 11:9 | 2:69 | 38.6 | 8.4 |
| D8Mit200 | 60.1 | 12:6 | 1:72 | 54.7 | 11.9 |
| D8Mit14‡ | 68.9 | 13:3 | 0:75 | 114.5 | 24.9‡ |
| D8Mit326 | 74.3 | 13:5 | 0:73 | 93.4 | 20.3 |
| (A/J × BXH-2)F2, n = 187; BCG | |||||
| D8Mit86 | 54.6 | 29:11 | 11:136 | 102.9 | 22.4 |
| D8Mit200 | 60.1 | 31:6 | 9:141 | 146.8 | 31.9 |
| D8Mit14‡ | 68.9 | 31:9 | 9:138 | 113.1 | 24.6‡ |
| D8Mit326 | 74.3 | 29:13 | 11:134 | 75.9 | 16.5 |
Markers . | Distance from telomere, cM* . | B6/B6,†high-low . | B6/A + A/A,†high-low . | χ2 . | LOD . |
|---|---|---|---|---|---|
| (BALB/c × BXH-2)F2, n = 118 | |||||
| D8Mit86 | 54.6 | 27:10 | 6:75 | 60.8 | 13.2 |
| D8Mit200 | 60.1 | 31:5 | 2:80 | 128.3 | 27.9 |
| D8Mit13‡ | 68.9 | 31:2 | 2:83 | 158.8 | 34.5‡ |
| D8Mit326 | 74.3 | 28:3 | 5:82 | 114.7 | 24.9 |
| (A/J × BXH-2)F2, n = 91 | |||||
| D8Mit86 | 54.6 | 11:9 | 2:69 | 38.6 | 8.4 |
| D8Mit200 | 60.1 | 12:6 | 1:72 | 54.7 | 11.9 |
| D8Mit14‡ | 68.9 | 13:3 | 0:75 | 114.5 | 24.9‡ |
| D8Mit326 | 74.3 | 13:5 | 0:73 | 93.4 | 20.3 |
| (A/J × BXH-2)F2, n = 187; BCG | |||||
| D8Mit86 | 54.6 | 29:11 | 11:136 | 102.9 | 22.4 |
| D8Mit200 | 60.1 | 31:6 | 9:141 | 146.8 | 31.9 |
| D8Mit14‡ | 68.9 | 31:9 | 9:138 | 113.1 | 24.6‡ |
| D8Mit326 | 74.3 | 29:13 | 11:134 | 75.9 | 16.5 |
The chromosome position of each marker is expressed as distance from the telomere (shown in cM) and is from the MIT Centre for Genome Research (http://www-genome.wi.mit.edu/cgi-bin/mouse/index)
F2 animals were divided according to their allelic combination at D8mit13 or D8Mit14, derived from C57BL/6J (B6; derived from BXH-2), BALB/cJ, or A/J (A). The ratio of animals with low (< 0.8) or high (≥ 0.8) spleen index is shown along with the relevant statistics to demonstrate significance
Highest LOD score