Number and frequency of hematologic and nonhematologic AEs by time
AEs . | First quarter . | . | Second quarter . | . | Second half year . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Hema AE | |||||||||
| Grade 3 | 100 | 0.17 | 49 | 0.09 | 31 | 0.03 | |||
| Grade 4 | 15 | 0.03 | 4 | 0.007 | 1 | < 0.001 | |||
| Total | 115 | 0.20 | 53 | 0.10 | 32 | 0.03 | |||
| Nonhema AE | |||||||||
| Grade 1 | 324 | 0.56 | 121 | 0.23 | 99 | 0.10 | |||
| Grade 2 | 98 | 0.15 | 37 | 0.06 | 30 | 0.03 | |||
| Grade 3 | 15 | 0.03 | 6 | 0.01 | 6 | 0.006 | |||
| Grade 4 | 1 | 0.001 | 2 | 0.004 | 1 | < 0.001 | |||
| Total | 438 | 0.76 | 166 | 0.31 | 136 | 0.13 | |||
AEs . | First quarter . | . | Second quarter . | . | Second half year . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Hema AE | |||||||||
| Grade 3 | 100 | 0.17 | 49 | 0.09 | 31 | 0.03 | |||
| Grade 4 | 15 | 0.03 | 4 | 0.007 | 1 | < 0.001 | |||
| Total | 115 | 0.20 | 53 | 0.10 | 32 | 0.03 | |||
| Nonhema AE | |||||||||
| Grade 1 | 324 | 0.56 | 121 | 0.23 | 99 | 0.10 | |||
| Grade 2 | 98 | 0.15 | 37 | 0.06 | 30 | 0.03 | |||
| Grade 3 | 15 | 0.03 | 6 | 0.01 | 6 | 0.006 | |||
| Grade 4 | 1 | 0.001 | 2 | 0.004 | 1 | < 0.001 | |||
| Total | 438 | 0.76 | 166 | 0.31 | 136 | 0.13 | |||
The frequency provides an estimate of the number of AEs per patient per month and was calculated dividing, for each time period, the number of AEs by the number of months and by the number of patients at risk (191 in the first quarter, 178 in the second quarter, and 170 in the second half year).
Hema indicates hematologic; nonhema, nonhematologic.