TNF and IL4R genotypic proportions (%) by stroke subgroup
Two-locus genotypes IL4R S503P - TNF G(-308)A . | Large-vessel stroke . | Small-vessel stroke . | MRI(-) . | Total . |
|---|---|---|---|---|
| (SS) - (GG) | 11.1 | 22.9 | 31.4 | 27.0 |
| (SS) - (GA or AA) | 5.6 | 8.6 | 6.2 | 6.5 |
| (SP or PP) - (GG) | 80.6 | 48.6 | 42.8 | 49.6 |
| (SP or PP) - (GA or AA) | 2.8 | 20.0 | 19.5 | 17.0 |
| No. in group | 36 | 35 | 159 | 230 |
Two-locus genotypes IL4R S503P - TNF G(-308)A . | Large-vessel stroke . | Small-vessel stroke . | MRI(-) . | Total . |
|---|---|---|---|---|
| (SS) - (GG) | 11.1 | 22.9 | 31.4 | 27.0 |
| (SS) - (GA or AA) | 5.6 | 8.6 | 6.2 | 6.5 |
| (SP or PP) - (GG) | 80.6 | 48.6 | 42.8 | 49.6 |
| (SP or PP) - (GA or AA) | 2.8 | 20.0 | 19.5 | 17.0 |
| No. in group | 36 | 35 | 159 | 230 |
A 3-way interaction test in 2 (IL4R) × 2 (TNF) × 3 (stroke subgroups) log-linear model: log likelihood ratio statistic = 6.719; degrees of freedom = 2; P = .035.
Alleles are abbreviated in parentheses. The less common polymorphisms are indicated in italics (eg, SP or PP - GG indicates patients carrying 1 or 2 copies of the less common IL4R 503 P allele and are homozygous for the TNF(-308) G allele).
IL4R indicates interleukin-4 receptor; TNF, tumor necrosis factor.