Logistic regression analysis of gene variant effects by stroke subtype
. | . | Large-vessel stroke . | . | Small-vessel stroke . | . | ||
|---|---|---|---|---|---|---|---|
| Genetic locus . | Allele frequency* . | OR ± SE . | Z statistic, P . | OR ± SE . | Z statistic, P . | ||
| IL4R 503P | 0.39 | 2.50 ± 0.83 | .006 | 1.30 ± 0.46 | .45 | ||
| HLA-A | 0.06 | 7.71 ± 1.96 | .013 | 1.98 ± 1.01 | .18 | ||
| ADRB2 27E | 0.16 | 0.53 ± 0.16 | .033 | 0.94 ± 0.21 | .78 | ||
| TNF (-308)A | 0.13 | 0.52 ± 0.17 | .048 | 0.97 ± 0.22 | .90 | ||
| VCAM1 (-1594)C | 0.22 | 1.08 ± 0.24 | .72 | 1.98 ± 0.43 | .002 | ||
| HLA-DPB1 | 0.16 | 1.77 ± 0.70 | .16 | 3.50 ± 1.41 | .002 | ||
| HLA homozygosity | 0.16 | 1.20 ± 0.25 | .39 | 1.58 ± 0.32 | .023 | ||
| LDLR Ncol- | 0.20 | 1.01 ± 0.05 | .96 | 0.53 ± 0.139 | .002 | ||
. | . | Large-vessel stroke . | . | Small-vessel stroke . | . | ||
|---|---|---|---|---|---|---|---|
| Genetic locus . | Allele frequency* . | OR ± SE . | Z statistic, P . | OR ± SE . | Z statistic, P . | ||
| IL4R 503P | 0.39 | 2.50 ± 0.83 | .006 | 1.30 ± 0.46 | .45 | ||
| HLA-A | 0.06 | 7.71 ± 1.96 | .013 | 1.98 ± 1.01 | .18 | ||
| ADRB2 27E | 0.16 | 0.53 ± 0.16 | .033 | 0.94 ± 0.21 | .78 | ||
| TNF (-308)A | 0.13 | 0.52 ± 0.17 | .048 | 0.97 ± 0.22 | .90 | ||
| VCAM1 (-1594)C | 0.22 | 1.08 ± 0.24 | .72 | 1.98 ± 0.43 | .002 | ||
| HLA-DPB1 | 0.16 | 1.77 ± 0.70 | .16 | 3.50 ± 1.41 | .002 | ||
| HLA homozygosity | 0.16 | 1.20 ± 0.25 | .39 | 1.58 ± 0.32 | .023 | ||
| LDLR Ncol- | 0.20 | 1.01 ± 0.05 | .96 | 0.53 ± 0.139 | .002 | ||
The MRI (-) group was used as the comparison group in the logistic regression model.
Likelihood ratio χ2 = 73.1; probability greater than χ2 = 0.000; pseudo R2 = 0.19.
OR indicates odds ratio; SE, standard error.
Variant allele frequencies are shown for the total study population (N = 230). For the HLA loci, carrier frequencies are given, as previously published15