Candidate gene polymorphisms assessed
Locus . | Marker . | rs no. . |
|---|---|---|
| Lipid metabolism | ||
| ADRB3 | W64R | 4994 |
| APOA4 | T347S | 675 |
| Q360H | 5110 | |
| APOB | T711 | 1367117 |
| R3500Q | 5742904 | |
| APOC3 | -641C>A | 2542052 |
| -482C>T | 2854117 | |
| -455T>C | 2854116 | |
| 1100C>T | 4520 | |
| 3175C>G | 5128 | |
| 3206T>G | 4225 | |
| APOE | C112R | 429358 |
| R158C | 7412 | |
| CETP | -629C>A | 1800775 |
| I405V | 5882 | |
| D442G | 2303790 | |
| LDLR | Ncol+/- | 5742911 |
| LIPC | -480C>T | 1800588 |
| LPA | 93C>T | 1652503 |
| 121G>A | 1800769 | |
| LPL | -93T>G | 1800590 |
| D9N | 1801177 | |
| N291S | 268 | |
| S447X | 328 | |
| PON1 | M55L | 3202100 |
| Q192R | 662 | |
| PON2 | S311C | 7493 |
| PPARG | P12A | 1801282 |
| Cellular adhesion | ||
| ICAM1 | K56M | 5491 |
| G241R | 1799969 | |
| SELE | S128R | 5361 |
| L554F | 5355 | |
| SELP | S330N | 6131 |
| V640L | 6133 | |
| VCAM1 | -1594T>C | 1041163 |
| Inflammation | ||
| C3 | R102G | 2230199 |
| C5 | I802V | 17611 |
| CCR2 | V62I | 1799864 |
| CCR3 | P39L | 5742906 |
| CCR5 | wt/Δ580-611 | 333 |
| -2454G>A | 1799987 | |
| CD14 | -260C>T | 2569190 |
| CSF2 | I117T | 25882 |
| CTLA4 | -318C>T | 5742909 |
| T17A | 231775 | |
| FCERB1 | E237G | 569108 |
| GC | E416D | 7041 |
| T420K | 4588 | |
| IL1A | -889T>C | 1800587 |
| IL1B | -1418C>T | 16944 |
| F105F | 1143634 | |
| IL4 | -590C>T | 2243250 |
| IL4R | I75V | 1805010 |
| S503P | 1805015 | |
| Q576R | 1801275 | |
| IL5RA | -80G>A | 2290608 |
| IL6 | -572G>C | 1800796 |
| -174G>C | 1800795 | |
| IL9 | T113M | 2069885 |
| IL10 | -571C>A | 1800872 |
| IL13 | 4045C>T | 1295686 |
| Inflammation | ||
| LTA | T26N | 1041981 |
| 252A>G | 909253 | |
| LTC4S | -444A>C | 730012 |
| MMP3 | -1171A5>A6 | 3025058 |
| SCYA11 | A23T | 3744508 |
| -1328G>A | 4795895 | |
| SDF1 | +800 G>A | 1801157 |
| TCF7 | P19T | 5742913 |
| TGFB1 | -509C>T | 1800469 |
| TNF | -376G>A | 1800750 |
| -308G>A | 1800629 | |
| -244G>A | 673 | |
| -238G>A | 361525 | |
| UGB | +38G>A | 3741240 |
| VDR | M1T | 2228570 |
| Bsml+/- | 1544410 | |
| Homocysteine metabolism | ||
| CBS | I278ins/T | 5742905 |
| MTHFR | 677 C>T | 1801133 |
| Thrombosis | ||
| F2 | 20210G>A | 1799963 |
| F5 | R506Q | 6025 |
| F7 | -323 ins/del | 5742910 |
| R353Q | 6046 | |
| FGB | -455G>A | 1800790 |
| ITGA2 | 873G>A | 1062535 |
| ITGB3 | L33P | 5918 |
| PAI1 | -675G5>G4 | 1799768 |
| 11053G>T | 7242 | |
| Blood pressure regulation | ||
| ADD1 | G460W | 4961 |
| ADRB2 | R16G | 1042713 |
| Q27E | 1042714 | |
| T164I | 1800888 | |
| AGT | M235T | 699 |
| AGTR1 | 1166A>C | 5186 |
| ACE | intron 16 ins/del | 1799752 |
| GNB3 | 825C>T | 5443 |
| NOS2A | 231C>T | 1137933 |
| NOS3 | -922A>G | 1800779 |
| -690C>T | 3918226 | |
| E298D | 1799983 | |
| NPPA | 664G>A | 5063 |
| 2238T>C | 5065 | |
| SCNN1A | T493R | 5742912 |
| A663T | 2228756 |
Locus . | Marker . | rs no. . |
|---|---|---|
| Lipid metabolism | ||
| ADRB3 | W64R | 4994 |
| APOA4 | T347S | 675 |
| Q360H | 5110 | |
| APOB | T711 | 1367117 |
| R3500Q | 5742904 | |
| APOC3 | -641C>A | 2542052 |
| -482C>T | 2854117 | |
| -455T>C | 2854116 | |
| 1100C>T | 4520 | |
| 3175C>G | 5128 | |
| 3206T>G | 4225 | |
| APOE | C112R | 429358 |
| R158C | 7412 | |
| CETP | -629C>A | 1800775 |
| I405V | 5882 | |
| D442G | 2303790 | |
| LDLR | Ncol+/- | 5742911 |
| LIPC | -480C>T | 1800588 |
| LPA | 93C>T | 1652503 |
| 121G>A | 1800769 | |
| LPL | -93T>G | 1800590 |
| D9N | 1801177 | |
| N291S | 268 | |
| S447X | 328 | |
| PON1 | M55L | 3202100 |
| Q192R | 662 | |
| PON2 | S311C | 7493 |
| PPARG | P12A | 1801282 |
| Cellular adhesion | ||
| ICAM1 | K56M | 5491 |
| G241R | 1799969 | |
| SELE | S128R | 5361 |
| L554F | 5355 | |
| SELP | S330N | 6131 |
| V640L | 6133 | |
| VCAM1 | -1594T>C | 1041163 |
| Inflammation | ||
| C3 | R102G | 2230199 |
| C5 | I802V | 17611 |
| CCR2 | V62I | 1799864 |
| CCR3 | P39L | 5742906 |
| CCR5 | wt/Δ580-611 | 333 |
| -2454G>A | 1799987 | |
| CD14 | -260C>T | 2569190 |
| CSF2 | I117T | 25882 |
| CTLA4 | -318C>T | 5742909 |
| T17A | 231775 | |
| FCERB1 | E237G | 569108 |
| GC | E416D | 7041 |
| T420K | 4588 | |
| IL1A | -889T>C | 1800587 |
| IL1B | -1418C>T | 16944 |
| F105F | 1143634 | |
| IL4 | -590C>T | 2243250 |
| IL4R | I75V | 1805010 |
| S503P | 1805015 | |
| Q576R | 1801275 | |
| IL5RA | -80G>A | 2290608 |
| IL6 | -572G>C | 1800796 |
| -174G>C | 1800795 | |
| IL9 | T113M | 2069885 |
| IL10 | -571C>A | 1800872 |
| IL13 | 4045C>T | 1295686 |
| Inflammation | ||
| LTA | T26N | 1041981 |
| 252A>G | 909253 | |
| LTC4S | -444A>C | 730012 |
| MMP3 | -1171A5>A6 | 3025058 |
| SCYA11 | A23T | 3744508 |
| -1328G>A | 4795895 | |
| SDF1 | +800 G>A | 1801157 |
| TCF7 | P19T | 5742913 |
| TGFB1 | -509C>T | 1800469 |
| TNF | -376G>A | 1800750 |
| -308G>A | 1800629 | |
| -244G>A | 673 | |
| -238G>A | 361525 | |
| UGB | +38G>A | 3741240 |
| VDR | M1T | 2228570 |
| Bsml+/- | 1544410 | |
| Homocysteine metabolism | ||
| CBS | I278ins/T | 5742905 |
| MTHFR | 677 C>T | 1801133 |
| Thrombosis | ||
| F2 | 20210G>A | 1799963 |
| F5 | R506Q | 6025 |
| F7 | -323 ins/del | 5742910 |
| R353Q | 6046 | |
| FGB | -455G>A | 1800790 |
| ITGA2 | 873G>A | 1062535 |
| ITGB3 | L33P | 5918 |
| PAI1 | -675G5>G4 | 1799768 |
| 11053G>T | 7242 | |
| Blood pressure regulation | ||
| ADD1 | G460W | 4961 |
| ADRB2 | R16G | 1042713 |
| Q27E | 1042714 | |
| T164I | 1800888 | |
| AGT | M235T | 699 |
| AGTR1 | 1166A>C | 5186 |
| ACE | intron 16 ins/del | 1799752 |
| GNB3 | 825C>T | 5443 |
| NOS2A | 231C>T | 1137933 |
| NOS3 | -922A>G | 1800779 |
| -690C>T | 3918226 | |
| E298D | 1799983 | |
| NPPA | 664G>A | 5063 |
| 2238T>C | 5065 | |
| SCNN1A | T493R | 5742912 |
| A663T | 2228756 |
All markers were screened using linear array technology from Roche Molecular Systems. See Appendix 2 for abbreviations of markers listed. All markers are referenced by reference SNP ID (rs) number in the National Center for Biotechnology Information (NCBI) SNP database.