Mean INR/Cp values and warfarin daily dose in various genotypes determined from single and multiple gene polymorphisms
Gene . | Allele . | Genotype . | n . | INR/Cp . | Warfarin dose, mg (range) . |
|---|---|---|---|---|---|
| Factor II | 494C (M1) | M1/M1 | 8 | 2.62 ± 0.54 | 3.3 ± 1.1 (1.5-5.0) |
| 494T (M2) | M1/M2 | 18 | 3.00 ± 0.39 | 3.9 ± 1.8 (1.5-7.5) | |
| M2/M2 | 19 | 3.26 ± 0.18* | 3.8 ± 2.1 (1.0-8.5) | ||
| Factor VII | –402G (B1) | B1/B1 | 14 | 3.42 ± 0.82 | 3.5 ± 2.0 (1.5-8.0) |
| –402A (B2) | B1/B2 | 22 | 3.09 ± 0.43† | 3.9 ± 1.9 (1.0-8.5) | |
| B2/B2 | 9 | 2.39 ± 0.18* | 3.8 ± 1.3 (1.5-6.0) | ||
| (37-bp repeat)6 (a) | a/a | 36 | 3.14 ± 0.55 | 3.8 ± 1.9 (1.0-8.5) | |
| (37-bp repeat)7 (b) | b/b | 9 | 2.58 ± 0.21 | 3.5 ± 1.3 (1.5-5.0) | |
| –746T (N1) | N1/N1 | 16 | 3.34 ± 0.66 | 3.6 ± 1.9 (1.5-8.0) | |
| –746C (N2) | N1/N2 | 20 | 3.00 ± 0.51 | 4.0 ± 2.0 (1.0-8.5) | |
| N2/N2 | 9 | 2.58 ± 0.21* | 4.0 ± 1.3 (1.5-5.0) | ||
| Combination | I | (M1/M1)(B2/B2)(b/b)(N2/N2) | 5 | 2.14 ± 0.31 | 3.6 ± 1.4 (1.5-5.0) |
| II | (M1/M2)(B1/B1)(a/a)(N1/N1) | 7 | 3.56 ± 0.41 | 3.0 ± 1.3 (1.5-4.5) | |
| III | (M1/M2)(B1/B2)(a/a)(N1/N2) | 3 | 2.63 ± 0.72 | 5.3 ± 2.6 (2.5-7.5) | |
| IV | (M2/M2)(B1/B1)(a/a)(N1/N1) | 3 | 4.48 ± 0.83 | 2.3 ± 1.4 (1.5-4.0) | |
| V | (M2/M2)(B1/B2)(a/a)(N1/N2) | 9 | 2.93 ± 0.41 | 4.3 ± 1.9 (2.5-8.5) |
Gene . | Allele . | Genotype . | n . | INR/Cp . | Warfarin dose, mg (range) . |
|---|---|---|---|---|---|
| Factor II | 494C (M1) | M1/M1 | 8 | 2.62 ± 0.54 | 3.3 ± 1.1 (1.5-5.0) |
| 494T (M2) | M1/M2 | 18 | 3.00 ± 0.39 | 3.9 ± 1.8 (1.5-7.5) | |
| M2/M2 | 19 | 3.26 ± 0.18* | 3.8 ± 2.1 (1.0-8.5) | ||
| Factor VII | –402G (B1) | B1/B1 | 14 | 3.42 ± 0.82 | 3.5 ± 2.0 (1.5-8.0) |
| –402A (B2) | B1/B2 | 22 | 3.09 ± 0.43† | 3.9 ± 1.9 (1.0-8.5) | |
| B2/B2 | 9 | 2.39 ± 0.18* | 3.8 ± 1.3 (1.5-6.0) | ||
| (37-bp repeat)6 (a) | a/a | 36 | 3.14 ± 0.55 | 3.8 ± 1.9 (1.0-8.5) | |
| (37-bp repeat)7 (b) | b/b | 9 | 2.58 ± 0.21 | 3.5 ± 1.3 (1.5-5.0) | |
| –746T (N1) | N1/N1 | 16 | 3.34 ± 0.66 | 3.6 ± 1.9 (1.5-8.0) | |
| –746C (N2) | N1/N2 | 20 | 3.00 ± 0.51 | 4.0 ± 2.0 (1.0-8.5) | |
| N2/N2 | 9 | 2.58 ± 0.21* | 4.0 ± 1.3 (1.5-5.0) | ||
| Combination | I | (M1/M1)(B2/B2)(b/b)(N2/N2) | 5 | 2.14 ± 0.31 | 3.6 ± 1.4 (1.5-5.0) |
| II | (M1/M2)(B1/B1)(a/a)(N1/N1) | 7 | 3.56 ± 0.41 | 3.0 ± 1.3 (1.5-4.5) | |
| III | (M1/M2)(B1/B2)(a/a)(N1/N2) | 3 | 2.63 ± 0.72 | 5.3 ± 2.6 (2.5-7.5) | |
| IV | (M2/M2)(B1/B1)(a/a)(N1/N1) | 3 | 4.48 ± 0.83 | 2.3 ± 1.4 (1.5-4.0) | |
| V | (M2/M2)(B1/B2)(a/a)(N1/N2) | 9 | 2.93 ± 0.41 | 4.3 ± 1.9 (2.5-8.5) |