Transplantation history of JAK3-deficient SCID patients
. | . | No. and type of stem cell transplantation (age at time of transplantation)* . | . | . | ||
|---|---|---|---|---|---|---|
| Patient no.† . | Current age, y‡ . | HLA-haploidentical T-depleted bone marrow . | HLA-identical bone marrow . | Unrelated cord blood . | ||
| 1 | 7 | 2 (10 mo; 21 mo) | NA | 1 (27 mo) | ||
| 2 | 19 | 1 (5 mo) | NA | NA | ||
| 3 | 12 | NA | 1 (7 mo) | NA | ||
| 4 | 5 | 1 (24 d) | NA | NA | ||
| 5 | 11 | NA | 1 (9 mo) | NA | ||
| 6 | 17 | 2 (7 mo; 9 y) | NA | NA | ||
| 7§ | NA | 2 (14 mo; 20 mo) | NA | NA | ||
| 8 | 13 | 1 (8 mo) | NA | NA | ||
| 9 | 10 | 1 (25 d) | NA | NA | ||
| 10 | 8 | 1 (21 d) | NA | NA | ||
. | . | No. and type of stem cell transplantation (age at time of transplantation)* . | . | . | ||
|---|---|---|---|---|---|---|
| Patient no.† . | Current age, y‡ . | HLA-haploidentical T-depleted bone marrow . | HLA-identical bone marrow . | Unrelated cord blood . | ||
| 1 | 7 | 2 (10 mo; 21 mo) | NA | 1 (27 mo) | ||
| 2 | 19 | 1 (5 mo) | NA | NA | ||
| 3 | 12 | NA | 1 (7 mo) | NA | ||
| 4 | 5 | 1 (24 d) | NA | NA | ||
| 5 | 11 | NA | 1 (9 mo) | NA | ||
| 6 | 17 | 2 (7 mo; 9 y) | NA | NA | ||
| 7§ | NA | 2 (14 mo; 20 mo) | NA | NA | ||
| 8 | 13 | 1 (8 mo) | NA | NA | ||
| 9 | 10 | 1 (25 d) | NA | NA | ||
| 10 | 8 | 1 (21 d) | NA | NA | ||
NA indicates not applicable.
Preconditioning (busulfan, cyclophosphamide, antithymocyte globulin [ATG]) was only utilized with patient 1 (prior to cord blood transplantation). In all patients receiving 2 HLA-haploidentical transplantations (patients 1, 6, and 7), the second transplant was from the same parental donor as the first transplant (father for patient 1, mother for patients 6 and 7). HLA-identical marrow for patient 5 was T depleted, while that for patient 3 was not.
All infants except patients 8, 9, and 10 (full siblings of patient 4) underwent transplantation at Duke University Medical Center.
Median = 11 years.
Deceased.