NK cell numbers and function in JAK3-deficient SCID patients
. | . | Before transplantation . | . | After transplantation . | . | ||
|---|---|---|---|---|---|---|---|
. | Time of study* . | CD16+, cells per mm3 . | NK activity, % target lysis† . | CD16+, cells per mm3 . | NK activity, % target lysis† . | ||
| Patient no. | |||||||
| 1 | 2 | 29 | 0.0 | 1598 | 71.0 | ||
| 2 | 7 | 0 | ND | 60 | 1.7 | ||
| 3 | 12 | 204 | 6.8 | 54 | ND | ||
| 4 | 2 | 15 | 0.0 | 186 | 2.5 | ||
| 5 | 6 | 29 | ND | 319 | 25.9 | ||
| 6 | 8 | 31 | 1.4 | 58 | 0.0 | ||
| 7 | NA | 22 | ND | NA | NA | ||
| 8 | 8 | NA | NA | 55 | 4.0 | ||
| 9 | 8 | NA | NA | 60 | 3.1 | ||
| 10 | 2 | NA | NA | 124 | 0.6 | ||
| Controls | NA | 87-1189‡ | 38.9 ± 13.9§ | 87-1189‡ | 38.9 ± 13.9§ | ||
. | . | Before transplantation . | . | After transplantation . | . | ||
|---|---|---|---|---|---|---|---|
. | Time of study* . | CD16+, cells per mm3 . | NK activity, % target lysis† . | CD16+, cells per mm3 . | NK activity, % target lysis† . | ||
| Patient no. | |||||||
| 1 | 2 | 29 | 0.0 | 1598 | 71.0 | ||
| 2 | 7 | 0 | ND | 60 | 1.7 | ||
| 3 | 12 | 204 | 6.8 | 54 | ND | ||
| 4 | 2 | 15 | 0.0 | 186 | 2.5 | ||
| 5 | 6 | 29 | ND | 319 | 25.9 | ||
| 6 | 8 | 31 | 1.4 | 58 | 0.0 | ||
| 7 | NA | 22 | ND | NA | NA | ||
| 8 | 8 | NA | NA | 55 | 4.0 | ||
| 9 | 8 | NA | NA | 60 | 3.1 | ||
| 10 | 2 | NA | NA | 124 | 0.6 | ||
| Controls | NA | 87-1189‡ | 38.9 ± 13.9§ | 87-1189‡ | 38.9 ± 13.9§ | ||
ND indicates not done; and NA, not applicable.
Number of years after stem cell transplantation (patient 1, unrelated cord blood transplantation; patient 6, T cell—depleted HLA-haploidentical transplantation number 1; single T cell—depleted HLA-haploidentical transplantation for patients 2, 4, 8, 9, and 10; single HLA identical transplantation for patients 3 and 5; patient 7 is deceased) when posttransplantation experiments were performed.
Percent specific K562 lysis at effector-target (E/T) ratio 50:1. Results were similar at other E/T ratios.
Values are the 95% confidence interval for 167 control subjects.
Mean ± SD; percent specific target lysis by healthy volunteer cells for the 17 experiments shown.