Table 1. In vitro growth of eBFU-E and... | American Society of Hematology

Table 1.

In vitro growth of eBFU-E and eCFU-MK, clonality analysis and PRV-1 expression in patients with polycythemia vera and essential thrombocythemia

Study and disease	Patients, n	eBFU-E, %	eCFU-MK, %	eBFU-E and/or eCFU-MK, %	Clonality, %	PRV-1 overexpression, %
Liu et al¹
PV	14	100	ND	ND	100^*	69
ET	12	33	ND	ND	66^*	16
Kralovics et al²
PV	23	100	ND	ND	ND	91
ET	15	69	ND	ND	ND	67
Current study
PV	11	100	36	100	50†	91
ET	17	29	41	53	40†	59

Study and disease	Patients, n	eBFU-E, %	eCFU-MK, %	eBFU-E and/or eCFU-MK, %	Clonality, %	PRV-1 overexpression, %
Liu et al¹
PV	14	100	ND	ND	100^*	69
ET	12	33	ND	ND	66^*	16
Kralovics et al²
PV	23	100	ND	ND	ND	91
ET	15	69	ND	ND	ND	67
Current study
PV	11	100	36	100	50†	91
ET	17	29	41	53	40†	59

eBFU-E indicates endogenous erythroid colony growth in the absence of added Epo; eCFU-MK, endogenous megakaryocytic colony growth in the absence of added LCM; and ND, not done. Clonality was calculated after correcting granulocytes value for the degree of lyonization of CD3⁺ cells. Clonality was considered when the corrected allele ratio was less than 0.30, which corresponds to more than 70% expression of one allele.

Obtained using G6PD, IDS, MPP1, BTK and FHL 1 genes

†

Obtained using HUMARA gene

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