VWF measurements and BT before and after DDAVP in selected patients with type 2A VWD
. | Time after DDAVP, h . | VWF:RCo, U/dL . | VWF:Ag, U/dL . | VWF:RCo/Ag ratio . | Bleeding time, min . |
---|---|---|---|---|---|
Normal values (range) | 110 ± 35 (46-202) | 112 ± 36 (50-218) | 0.99 ± 0.23 (0.63-1.75) | 5 ± 2 (3-7) | |
Patient with S1506L, group 1 | Baseline | <6 | 22 | 0.27 | >30 |
0.5 | 14 | 44 | 0.32 | >30 | |
1 | 22 | 68 | 0.32 | >30 | |
2 | 24 | 77 | 0.29 | >30 | |
4 | 14 | 64 | 0.22 | >30 | |
Patient with R1597W, group 2 | Baseline | 6 | 31 | 0.19 | >30 |
0.5 | 65 | 100 | 0.65 | NT | |
1 | 60 | 134 | 0.45 | 6.30 | |
2 | 53 | 112 | 0.47 | 12 | |
4 | 36 | 96 | 0.37 | 15 | |
Patient with G1629R, group 2 | Baseline | 30 | 100 | 0.30 | >30 |
0.5 | 67 | 190 | 0.35 | NT | |
1 | 79 | 236 | 0.33 | 10 | |
2 | 60 | 232 | 0.26 | 20 | |
4 | 62 | 252 | 0.25 | >30 | |
Patient with V1665E, group 1 | Baseline | <6 | 22 | 0.27 | >30 |
1 | 10 | 91 | 0.11 | >30 | |
2 | 13 | 95 | 0.14 | >30 | |
4 | 10 | 104 | 0.10 | >30 |
. | Time after DDAVP, h . | VWF:RCo, U/dL . | VWF:Ag, U/dL . | VWF:RCo/Ag ratio . | Bleeding time, min . |
---|---|---|---|---|---|
Normal values (range) | 110 ± 35 (46-202) | 112 ± 36 (50-218) | 0.99 ± 0.23 (0.63-1.75) | 5 ± 2 (3-7) | |
Patient with S1506L, group 1 | Baseline | <6 | 22 | 0.27 | >30 |
0.5 | 14 | 44 | 0.32 | >30 | |
1 | 22 | 68 | 0.32 | >30 | |
2 | 24 | 77 | 0.29 | >30 | |
4 | 14 | 64 | 0.22 | >30 | |
Patient with R1597W, group 2 | Baseline | 6 | 31 | 0.19 | >30 |
0.5 | 65 | 100 | 0.65 | NT | |
1 | 60 | 134 | 0.45 | 6.30 | |
2 | 53 | 112 | 0.47 | 12 | |
4 | 36 | 96 | 0.37 | 15 | |
Patient with G1629R, group 2 | Baseline | 30 | 100 | 0.30 | >30 |
0.5 | 67 | 190 | 0.35 | NT | |
1 | 79 | 236 | 0.33 | 10 | |
2 | 60 | 232 | 0.26 | 20 | |
4 | 62 | 252 | 0.25 | >30 | |
Patient with V1665E, group 1 | Baseline | <6 | 22 | 0.27 | >30 |
1 | 10 | 91 | 0.11 | >30 | |
2 | 13 | 95 | 0.14 | >30 | |
4 | 10 | 104 | 0.10 | >30 |
See also Figure 3 for these data.
NT indicates not tested.