Table 1.

Bone marrow composition of leukemic (MII and MII/Box) and nonleukemic (wild-type and HoxA9-/-) mice


Mouse type/cell type

MII

MII/Hox

Wild-type

Hoxa9-/-
Flow cytometry     
    % Gr-1     49 ± 6   66 ± 6  
        Gr-1+  72 ± 3*  83 ± 9*  —   —  
        Gr-1-  20 ± 3*  31 ± 4*§  —   —  
    % CD11b   85 ± 3*  96 ± 1*  60 ± 5   77 ± 5  
    % B220   9 ± 2*  11 ± 5*  23 ± 2   28 ± 4  
Morphology     
    % blasts   17 ± 2*  14 ± 3*  2 ± 0.4   3 ± 0.6  
    % RBC precursors
 
12 ± 1*
 
12 ± 4*
 
39 ± 3
 
42 ± 5
 

Mouse type/cell type

MII

MII/Hox

Wild-type

Hoxa9-/-
Flow cytometry     
    % Gr-1     49 ± 6   66 ± 6  
        Gr-1+  72 ± 3*  83 ± 9*  —   —  
        Gr-1-  20 ± 3*  31 ± 4*§  —   —  
    % CD11b   85 ± 3*  96 ± 1*  60 ± 5   77 ± 5  
    % B220   9 ± 2*  11 ± 5*  23 ± 2   28 ± 4  
Morphology     
    % blasts   17 ± 2*  14 ± 3*  2 ± 0.4   3 ± 0.6  
    % RBC precursors
 
12 ± 1*
 
12 ± 4*
 
39 ± 3
 
42 ± 5
 

Data represent mean ± standard error. MII, n = 28; MII/Hox, n = 10; wild-type, n = 17; and Hoxa9-/-, n = 6.

*

Statistically significant difference between leukemic and nonleukemic mice (P < .05).

n = 24.

n = 4.

§

n = 6.

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