Mobilization outcomes in selected genetic mutant murine models
Mice . | Reference . | G-CSF mobilization . | Comments . |
|---|---|---|---|
| G-CSFR-/- | 7 | No mobilization | No response to cyclophosphamide or IL-8-induced mobilization, G-CSFR-/- cells do mobilize, however, in the company of +/+ cells |
| MMP-9-/- | 9 | Attenuated response | Efficient G-CSF mobilization in these mice by other studies21,34 |
| CXCR2-/- | 6 | No mobilization | Normal baseline progenitors in PB; mobilize after cyclophosphamide in contrast to G-CSFR-/- mice |
| Elastase-/- + Cathepsin G-/- | 18 | Mobilize like controls | No additional data |
| DPP1-/- | 18 | Mobilize like controls | No additional data |
| CD26-/- | 19 | Attenuated response | Normal circulating progenitors at baseline |
| Rac2-/- | 36 | Enhanced mobilization | Increased baseline levels of progenitors |
| Rac1-/-/Rac2-/- | 44 | No data | Striking increase in circulating progenitors |
| α4 integrin (inducible ablation) | 43 | Enhanced mobilization | Increased baseline levels of progenitors |
| VCAM1-/- (conditional ablation) | 53 | Enhanced mobilization | Increased baseline levels of progenitors |
| W/Wv | 45 | Attenuated response | Reduced response with other mobilization schemes; ↓ baseline progenitors |
| Me/Mev | 45 | Enhanced mobilization | Increased baseline levels of progenitors |
| SFK-/- | † | Enhanced mobilization | Increased baseline levels of progenitors |
| EPL selectin-/- | 46 | Enhanced mobilization | Modest ↑ in baseline levels of progenitors |
| CD18-/- | 46 | Enhanced mobilization | Modest ↑ in baseline levels of progenitors |
| Id1+/-/Id3-/- mice | 25 | No data | No mobilization with adeno-VEGF |
| CCR1 | 54 | Enhanced mobilization | No detailed data available |
| C3-/- or C3aR-/- | 55 | Enhanced mobilization | No detailed data available |
Mice . | Reference . | G-CSF mobilization . | Comments . |
|---|---|---|---|
| G-CSFR-/- | 7 | No mobilization | No response to cyclophosphamide or IL-8-induced mobilization, G-CSFR-/- cells do mobilize, however, in the company of +/+ cells |
| MMP-9-/- | 9 | Attenuated response | Efficient G-CSF mobilization in these mice by other studies21,34 |
| CXCR2-/- | 6 | No mobilization | Normal baseline progenitors in PB; mobilize after cyclophosphamide in contrast to G-CSFR-/- mice |
| Elastase-/- + Cathepsin G-/- | 18 | Mobilize like controls | No additional data |
| DPP1-/- | 18 | Mobilize like controls | No additional data |
| CD26-/- | 19 | Attenuated response | Normal circulating progenitors at baseline |
| Rac2-/- | 36 | Enhanced mobilization | Increased baseline levels of progenitors |
| Rac1-/-/Rac2-/- | 44 | No data | Striking increase in circulating progenitors |
| α4 integrin (inducible ablation) | 43 | Enhanced mobilization | Increased baseline levels of progenitors |
| VCAM1-/- (conditional ablation) | 53 | Enhanced mobilization | Increased baseline levels of progenitors |
| W/Wv | 45 | Attenuated response | Reduced response with other mobilization schemes; ↓ baseline progenitors |
| Me/Mev | 45 | Enhanced mobilization | Increased baseline levels of progenitors |
| SFK-/- | † | Enhanced mobilization | Increased baseline levels of progenitors |
| EPL selectin-/- | 46 | Enhanced mobilization | Modest ↑ in baseline levels of progenitors |
| CD18-/- | 46 | Enhanced mobilization | Modest ↑ in baseline levels of progenitors |
| Id1+/-/Id3-/- mice | 25 | No data | No mobilization with adeno-VEGF |
| CCR1 | 54 | Enhanced mobilization | No detailed data available |
| C3-/- or C3aR-/- | 55 | Enhanced mobilization | No detailed data available |
SFK indicates Src family kinases (Hck/Fgr/Lyn); and EPL, endothelial, platelet, leukocyte selectin.
*R. Kapur, oral communication (October 2003).