Maximum tolerated nonlethal dose of CMC-544 in nude mice
Dose of CMC-544, μg conjugated CalichDMH/kg . | Survival of nude mice, % . |
|---|---|
| 0 | 100 |
| 80 | 100 |
| 160 | 100 |
| 240 | 100 |
| 320 | 40 |
| 400 | 30 |
| 480 | 0 |
Dose of CMC-544, μg conjugated CalichDMH/kg . | Survival of nude mice, % . |
|---|---|
| 0 | 100 |
| 80 | 100 |
| 160 | 100 |
| 240 | 100 |
| 320 | 40 |
| 400 | 30 |
| 480 | 0 |
CMC-544 was administered intraperitoneally as 3 doses, 1 every 4 days at various doses to nontumor-bearing nude mice (10 mice/group) after which their survival was monitored for up to 50 days. Maximum nonlethal dose (MND) of CMC-544 was the highest dose at which all mice treated with CMC-544 survived after 50 days.