Vascular mRNA with overexpression of TFPI after balloon injury
. | TFPI-myc . | TF . | . | MCP-1 . | . | MMP-2 . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Ad5TFPI . | Ad5TFPI . | Ad5lacZ . | Ad5TFPI . | Ad5lacZ . | Ad5TFPI . | Ad5lacZ . | |||
| Day 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | |||
| Day 2 | 1 | 4.0 ± 2.1 | 5.1 ± 2.3 | 5.9 ± 1.2 | 11.0 ± 2.1 | 8.8 ± 1.3 | 5.2 ± 4.0 | |||
| Day 5 | 1.9 ± 0.6 | 2.2 ± 0.6 | 3.3 ± 1.1 | 6.2 ± 1.0 | 15.7 ± 3.6* | 9.4 ± 2.2 | 14.7 ± 5.0* | |||
| Day 21 | 0.6 ± 0.2 | 0.7 ± 0.3 | 1.9 ± 0.7† | 4.2 ± 1.2 | 17.2 ± 6.2‡ | 13.7 ± 4.2 | 32.1 ± 8.2‡ | |||
. | TFPI-myc . | TF . | . | MCP-1 . | . | MMP-2 . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Ad5TFPI . | Ad5TFPI . | Ad5lacZ . | Ad5TFPI . | Ad5lacZ . | Ad5TFPI . | Ad5lacZ . | |||
| Day 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | |||
| Day 2 | 1 | 4.0 ± 2.1 | 5.1 ± 2.3 | 5.9 ± 1.2 | 11.0 ± 2.1 | 8.8 ± 1.3 | 5.2 ± 4.0 | |||
| Day 5 | 1.9 ± 0.6 | 2.2 ± 0.6 | 3.3 ± 1.1 | 6.2 ± 1.0 | 15.7 ± 3.6* | 9.4 ± 2.2 | 14.7 ± 5.0* | |||
| Day 21 | 0.6 ± 0.2 | 0.7 ± 0.3 | 1.9 ± 0.7† | 4.2 ± 1.2 | 17.2 ± 6.2‡ | 13.7 ± 4.2 | 32.1 ± 8.2‡ | |||
Values presented as x-fold over baseline ± SEM. T-test Ad5TFPI versus Ad5lacZ: *P < .05; †P < .01; ‡P < .001.
Human TFPI-myc was not determined in Ad5lacZ-transfected arteries.