Reduced protein C activation in BALF of TMpro/pro mice
Administration . | Wt mice, ng/mL . | TMpro/pro mice, ng/mL . |
|---|---|---|
| Saline | 0.3 ± 0.1 | 0.3 ± 0.3 |
| Thrombin | 0.8 ± 0.4 | 0* |
| Protein C | 4.7 ± 0.6 | 1.5 ± 0.4 |
| Thrombin and PC | 838.5 ± 66.9 | 32.9 ± 7.3* |
Administration . | Wt mice, ng/mL . | TMpro/pro mice, ng/mL . |
|---|---|---|
| Saline | 0.3 ± 0.1 | 0.3 ± 0.3 |
| Thrombin | 0.8 ± 0.4 | 0* |
| Protein C | 4.7 ± 0.6 | 1.5 ± 0.4 |
| Thrombin and PC | 838.5 ± 66.9 | 32.9 ± 7.3* |
Thrombin and/or protein C (PC) were administered intratracheally in Wt and TMpro/pro mice. A BAL was performed after 30 minutes, and human APC (ng/mL) was measured herein. Data are means ± SE of 4 mice per group for each treatment.
P < .05 versus Wt mice.